Circulating Endothelial-Derived Activated Microparticle : A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer
المؤلفون المشاركون
Fang, Wen-Feng
Tseng, Chia-Cheng
Chang, Huang-Chih
Chang, Li-Teh
Yip, Hon-Kan
Lin, Meng-Chih
Wang, Chin-Chou
Wang, Yi-Hsi
Chen, Chih-Hung
Leu, Steve
Hsiao, Chang-Chun
Ho, Chi-Kung
Tsai, Tzu-Hsien
Yang, Cheng-Ta
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
This study tested the hypothesis that circulating microparticles (MPs) are useful biomarkers for predicting one-year mortality in patients with end-stage non-small cell lung cancer (ES-NSCLC).
Methods and Results.
One hundred seven patients were prospectively enrolled into the study between April 2011 and February 2012, and each patient received regular follow-up after enrollment.
Levels of four MPs in circulation, (1) platelet-derived activated MPs (PDAc-MPs), (2) platelet-derived apoptotic MPs (PDAp-MPs), (3) endothelial-derived activated MPs (EDAc-MPs), and (4) endothelial-derived apoptotic MPs (EDAp-MPs), were measured just after the patient was enrolled into the study using flow cytometry.
Patients who survived for more than one year were categorized into group 1 (n=56) (one-year survivors) and patients who survived less than one year were categorized into group 2 (n=51) (one-year nonsurvivors).
Male gender, incidence of liver metastasis, progression of disease after first-line treatment, poor performance status, and the Charlson comorbidity index were significantly higher in group 2 than in group 1 (all P<0.05).
Additionally, as measured by flow cytometry, only the circulating level of EDAc-MPs was found to be significantly higher in group 2 than in group 1 (P=0.006).
Multivariate analysis demonstrated that circulating level of EDAc-MPs along with brain metastasis and male gender significantly and independently predictive of one-year mortality (all P<0.035).
Conclusion.
Circulating EDAc-MPs may be a useful biomarker predictive of one-year morality in ES-NSCLC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Chin-Chou& Tseng, Chia-Cheng& Hsiao, Chang-Chun& Chang, Huang-Chih& Chang, Li-Teh& Fang, Wen-Feng…[et al.]. 2014. Circulating Endothelial-Derived Activated Microparticle : A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-451740
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Chin-Chou…[et al.]. Circulating Endothelial-Derived Activated Microparticle : A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-451740
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Chin-Chou& Tseng, Chia-Cheng& Hsiao, Chang-Chun& Chang, Huang-Chih& Chang, Li-Teh& Fang, Wen-Feng…[et al.]. Circulating Endothelial-Derived Activated Microparticle : A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-451740
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451740
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر