DNA Vaccines : Developing New Strategies against Cancer
المؤلفون المشاركون
Rinaldi, Monica
Fioretti, Daniela
Iurescia, Sandra
Fazio, Vito Michele
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-03-28
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Due to their rapid and widespread development, DNA vaccines have entered into a variety of human clinical trials for vaccines against various diseases including cancer.
Evidence that DNA vaccines are well tolerated and have an excellent safety profile proved to be of advantage as many clinical trials combines the first phase with the second, saving both time and money.
It is clear from the results obtained in clinical trials that such DNA vaccines require much improvement in antigen expression and delivery methods to make them sufficiently effective in the clinic.
Similarly, it is clear that additional strategies are required to activate effective immunity against poorly immunogenic tumor antigens.
Engineering vaccine design for manipulating antigen presentation and processing pathways is one of the most important aspects that can be easily handled in the DNA vaccine technology.
Several approaches have been investigated including DNA vaccine engineering, co-delivery of immunomodulatory molecules, safe routes of administration, prime-boost regimen and strategies to break the immunosuppressive networks mechanisms adopted by malignant cells to prevent immune cell function.
Combined or single strategies to enhance the efficacy and immunogenicity of DNA vaccines are applied in completed and ongoing clinical trials, where the safety and tolerability of the DNA platform are substantiated.
In this review on DNA vaccines, salient aspects on this topic going from basic research to the clinic are evaluated.
Some representative DNA cancer vaccine studies are also discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fioretti, Daniela& Iurescia, Sandra& Fazio, Vito Michele& Rinaldi, Monica. 2010. DNA Vaccines : Developing New Strategies against Cancer. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-451844
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fioretti, Daniela…[et al.]. DNA Vaccines : Developing New Strategies against Cancer. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-451844
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fioretti, Daniela& Iurescia, Sandra& Fazio, Vito Michele& Rinaldi, Monica. DNA Vaccines : Developing New Strategies against Cancer. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-451844
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451844
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر