Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr−− Mice Compared to Nondiabetic LDLr−− Mice
المؤلفون المشاركون
Nilsson, Jan
Dunér, Pontus
Söderberg, Ingrid
Gomez, Maria F.
To, Fong
Alm, Ragnar
Bengtsson, Eva
Engelbertsen, Daniel
Kotova, Olga
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Diabetes is associated with increased cardiovascular disease, but the underlying cellular and molecular mechanisms are poorly understood.
One proposed mechanism is that diabetes aggravates atherosclerosis by enhancing plaque inflammation.
The Akita mouse has recently been adopted as a relevant model for microvascular complications of diabetes.
Here we investigate the development of atherosclerosis and inflammation in vessels of Akita mice on LDLr−/− background.
Methods and Results.
Akita-LDLr−/− and LDLr−/− mice were fed high-fat diet from 6 to 24 weeks of age.
Blood glucose levels were higher in both male and female Akita-LDLr−/− mice (137% and 70%, resp.).
Male Akita-LDLr−/− mice had markedly increased plasma cholesterol and triglyceride levels, a three-fold increase in atherosclerosis, and enhanced accumulation of macrophages and T-cells in plaques.
In contrast, female Akita-LDLr−/− mice demonstrated a modest 29% increase in plasma cholesterol and no significant increase in triglycerides, atherosclerosis, or inflammatory cells in lesions.
Male Akita-LDLr−/− mice had increased levels of plasma IL-1β compared to nondiabetic mice, whereas no such difference was seen between female diabetic and nondiabetic mice.
Conclusion.
Akita-LDLr−/− mice display considerable gender differences in the development of diabetic atherosclerosis.
In addition, the increased atherosclerosis in male Akita-LDLr−/− mice is associated with an increase in inflammatory cells in lesions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Engelbertsen, Daniel& To, Fong& Dunér, Pontus& Kotova, Olga& Söderberg, Ingrid& Alm, Ragnar…[et al.]. 2012. Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr−− Mice Compared to Nondiabetic LDLr−− Mice. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-452011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Engelbertsen, Daniel…[et al.]. Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr−− Mice Compared to Nondiabetic LDLr−− Mice. Experimental Diabetes Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-452011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Engelbertsen, Daniel& To, Fong& Dunér, Pontus& Kotova, Olga& Söderberg, Ingrid& Alm, Ragnar…[et al.]. Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr−− Mice Compared to Nondiabetic LDLr−− Mice. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-452011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر