Synthesis of 2,3-Dihydro-6-methyl-2-thiopyrimidin-4(1H)-one (6-Methylthiouracil) Derivatives and Their Reactions
المؤلفون المشاركون
Valiyeva, Gulgaz
Maharramovm, Abel A.
Allaverdiyev, Mirze M.
Barmaki, Mohammad
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The synthesis and characterization of 2,3-dihydro-6-methyl-2-thioxopyrimidin-(1H)-one (I) and some of its derivatives has been performed in our lab.
Ring-closing cyclization, as a result of the condensation of ethyl-3-oxobutanoate with thiourea in KOH in an ethanol medium produced 2,3-dihydro-6-methy -2-thioxopyrimidin-(1H)-one (I).
The reaction of compound (I) with 2- chloroacetic acid in an alkaline KOH solution produced the carboxylate derivative, 2-(2,6-dihydro-4-methyl-6-oxopyrimidin-2-yl-thio)ethanoic acid (II).
The reaction of the resulted derivative of carboxylate (II) with the salt of copper sulphate, produced a new copper salt (III).
A substitution reaction between synthesized compound (I) and 2-chloroethanol in an aqueous solution of KOH, created 2-(2-hydroxyethylthio)-6-methylpyrimidin-4(3H)-one (IV).
The reaction of compound (I) with 2-(chloromethyl)oxirane in the presence of an aqueous solution of KOH, resulted yielded 2-(3-chloro-2-hydroxy-propylthio)-6-methylpyrimidin-4(3H)-one (V).
Sodium mercaptide compound (VI), was produced by the reaction of (I) with NaOH and then the sodium salt of 2,3-dihydro-6-methyl-2-thioxopyrimidin-(1H)-one (VI) was reacted with 2-(chloromethyl)oxirane to result in 2-((oxiran-2-yl) methyl-thio)-6-methyl-pyrimidin-4(3H)-one (VII).
Different acylation reagents (acetyl chloride, benzoyl chloride) were reacted with compound (I), in dimethylformamide, acylation happens on sulfur and furnished S-acylified derivatives of (VIII-IX).
All the synthesized and obtained products were confirmed by IR, 1H, and 13C NMR and elemental analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barmaki, Mohammad& Valiyeva, Gulgaz& Maharramovm, Abel A.& Allaverdiyev, Mirze M.. 2012. Synthesis of 2,3-Dihydro-6-methyl-2-thiopyrimidin-4(1H)-one (6-Methylthiouracil) Derivatives and Their Reactions. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barmaki, Mohammad…[et al.]. Synthesis of 2,3-Dihydro-6-methyl-2-thiopyrimidin-4(1H)-one (6-Methylthiouracil) Derivatives and Their Reactions. Journal of Chemistry No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-452018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barmaki, Mohammad& Valiyeva, Gulgaz& Maharramovm, Abel A.& Allaverdiyev, Mirze M.. Synthesis of 2,3-Dihydro-6-methyl-2-thiopyrimidin-4(1H)-one (6-Methylthiouracil) Derivatives and Their Reactions. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر