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Faulty Suppression of Irrelevant Material in Patients with Thought Disorder Linked to Attenuated Frontotemporal Activation
المؤلفون المشاركون
Kircher, T. T. J.
Brammer, M.
Williams, S. C. R.
Broome, M. R.
Arcuri, S. M.
Morris, R. G.
Giampietro, V.
Andrew, C. M.
Amaro, E.
McGuire, P. K.
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Formal thought disorder is a feature schizophrenia that manifests as disorganized, incoherent speech, and is associated with a poor clinical outcome.
The neurocognitive basis of this symptom is unclear but it is thought to involve an impairment in semantic processing classically described as a loosening of meaningful associations.
Using a paradigm derived from the n400 event-related, potential, we examined the extent to which regional activation during semantic processing is altered in schizophrenic patients with formal thought disorder.
Ten healthy control and 18 schizophrenic participants (9 with and 9 without formal thought disorder) performed a semantic decision sentence task during an event-related functional magnetic resonance imaging experiment.
We employed analysis of variance to estimate the main effects of semantic congruency and groups on activation and specific effects of formal thought disorder were addressed using post-hoc comparisons.
We found that the frontotemporal network, normally engaged by a semantic decision task, was underactivated in schizophrenia, particularly in patients with FTD.
This network is implicated in the inhibition of automatically primed stimuli and impairment of its function interferes with language processing and contributes to the production of incoherent speech.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arcuri, S. M.& Broome, M. R.& Giampietro, V.& Amaro, E.& Kircher, T. T. J.& Williams, S. C. R.…[et al.]. 2012. Faulty Suppression of Irrelevant Material in Patients with Thought Disorder Linked to Attenuated Frontotemporal Activation. Schizophrenia Research and Treatment،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-452026
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arcuri, S. M.…[et al.]. Faulty Suppression of Irrelevant Material in Patients with Thought Disorder Linked to Attenuated Frontotemporal Activation. Schizophrenia Research and Treatment No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-452026
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arcuri, S. M.& Broome, M. R.& Giampietro, V.& Amaro, E.& Kircher, T. T. J.& Williams, S. C. R.…[et al.]. Faulty Suppression of Irrelevant Material in Patients with Thought Disorder Linked to Attenuated Frontotemporal Activation. Schizophrenia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-452026
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452026
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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