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Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles
المؤلفون المشاركون
Defarge, Nicolas
Mesnage, Robin
Séralini, Gilles-Eric
Spiroux de Vendômois, Joël
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Pesticides are used throughout the world as mixtures called formulations.
They contain adjuvants, which are often kept confidential and are called inerts by the manufacturing companies, plus a declared active principle, which is usually tested alone.
We tested the toxicity of 9 pesticides, comparing active principles and their formulations, on three human cell lines (HepG2, HEK293, and JEG3).
Glyphosate, isoproturon, fluroxypyr, pirimicarb, imidacloprid, acetamiprid, tebuconazole, epoxiconazole, and prochloraz constitute, respectively, the active principles of 3 major herbicides, 3 insecticides, and 3 fungicides.
We measured mitochondrial activities, membrane degradations, and caspases 3/7 activities.
Fungicides were the most toxic from concentrations 300–600 times lower than agricultural dilutions, followed by herbicides and then insecticides, with very similar profiles in all cell types.
Despite its relatively benign reputation, Roundup was among the most toxic herbicides and insecticides tested.
Most importantly, 8 formulations out of 9 were up to one thousand times more toxic than their active principles.
Our results challenge the relevance of the acceptable daily intake for pesticides because this norm is calculated from the toxicity of the active principle alone.
Chronic tests on pesticides may not reflect relevant environmental exposures if only one ingredient of these mixtures is tested alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mesnage, Robin& Defarge, Nicolas& Spiroux de Vendômois, Joël& Séralini, Gilles-Eric. 2014. Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-452259
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mesnage, Robin…[et al.]. Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-452259
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mesnage, Robin& Defarge, Nicolas& Spiroux de Vendômois, Joël& Séralini, Gilles-Eric. Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-452259
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452259
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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