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Brazilian Green Propolis Inhibits Inflammatory Angiogenesis in a Murine Sponge Model
المؤلفون المشاركون
Cara, Denise Carmona
Noviello, Maria de Lourdes
Reis, Maria Leticia Costa
Andrade, Silvia Passos
Moura, Sandra Aparecida Lima de
Ferreira, Mônica Alves Neves Diniz
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Angiogenesis and inflammation are persistent features of several pathological conditions.
Propolis, a sticky material that honeybees collect from living plants, has been reported to have multiple biological effects including anti-inflammatory and anti-neoplasic activities.
Here, we investigated the effects of water extract of green propolis (WEP) on angiogenesis, inflammatory cell accumulation and endogenous production of cytokines in sponge implants of mice over a 14-day period.
Blood vessel formation as assessed by hemoglobin content and by morphometric analysis of the implants was reduced by WEP (500 mg kg−1 orally) compared to the untreated group.
The levels of vascular endothelial growth factor (VEGF) increased progressively in the treated group but decreased after Day 10 in the control group.
Accumulation of neutrophils and macrophages was determined by measuring myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activities, respectively.
Neutrophil accumulation was unaffected by propolis, but NAG activity was reduced by the treatment at Day 14.
The levels TGF-β1 intra-implant increased progressively in both groups but were higher (40%) at Day 14 in the control implants.
The pro-inflammatory levels of TNF-α peaked at Day 7 in the control implants, and at Day 14 in the propolis-treated group.
Our results indicate that the anti-inflammatory/anti-angiogenic effects of propolis are associated with cytokine modulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moura, Sandra Aparecida Lima de& Ferreira, Mônica Alves Neves Diniz& Andrade, Silvia Passos& Reis, Maria Leticia Costa& Noviello, Maria de Lourdes& Cara, Denise Carmona. 2011. Brazilian Green Propolis Inhibits Inflammatory Angiogenesis in a Murine Sponge Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-452526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moura, Sandra Aparecida Lima de…[et al.]. Brazilian Green Propolis Inhibits Inflammatory Angiogenesis in a Murine Sponge Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-452526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moura, Sandra Aparecida Lima de& Ferreira, Mônica Alves Neves Diniz& Andrade, Silvia Passos& Reis, Maria Leticia Costa& Noviello, Maria de Lourdes& Cara, Denise Carmona. Brazilian Green Propolis Inhibits Inflammatory Angiogenesis in a Murine Sponge Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-452526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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