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Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents
المؤلفون المشاركون
Yin, Li-Te
Wu, Ming-Chang
Yang, Yu-lin
Chen, Mei-Fen
Wu, Tung-Pi
Yang, Jia-Jang
Chen, Li-Jen
Lu, Han-Lin
Tsai, Jo-Ting
Chiang, Tai-An
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs).
Also, guanidinium derivatives show the ability to activate imidazoline receptors.
Thus, it is of special interest to characterize the I-2R using guanidinium derivatives in blood vessels for development of antihypertensive agent(s).
Six guanidinium derivatives including agmatine, amiloride, aminoguanidine, allantoin, canavanine, and metformin were applied in this study.
Western blot analysis was used for detecting the expression of imidazoline receptor in tissues of Wistar rats.
The isometric tension of aortic rings isolated from male rats was also estimated.
The expression of imidazoline receptor on rat aorta was identified.
However, guanidinium derivatives for detection of aortic relaxation were not observed except agmatine and amiloride which induced a marked relaxation in isolated aortic rings precontracted with phenylephrine or KCl.
Both relaxations induced by agmatine and amiloride were attenuated by glibenclamide at concentration enough to block ATP-sensitive potassium (KATP) channels.
Meanwhile, only agmatine-induced relaxation was abolished by BU224, a selective antagonist of imidazoline I2-receptors.
Taken together, we suggest that agmatine can induce vascular relaxation through activation of peripheral imidazoline I2-receptor to open KATP channels.
Thus, agmatine-like compound has the potential to develop as a new therapeutic agent for hypertension in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Mei-Fen& Tsai, Jo-Ting& Chen, Li-Jen& Wu, Tung-Pi& Yang, Jia-Jang& Yin, Li-Te…[et al.]. 2014. Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-452539
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Mei-Fen…[et al.]. Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-452539
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Mei-Fen& Tsai, Jo-Ting& Chen, Li-Jen& Wu, Tung-Pi& Yang, Jia-Jang& Yin, Li-Te…[et al.]. Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-452539
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452539
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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