An Unusual Presentation of Desmoplastic Small Round Cell Tumour of the Abdomen : Morphological, Immunohistochemical, Ultrastructural, and Molecular Studies
المؤلفون المشاركون
Wolfswinkel, Karen
Brain, Terry
Khalafallah, Alhossain A.
Seaton, David
Angunawela, Preethika
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-19
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Desmoplastic small round cell tumour (DSRCT) is an aggressive and a rare neoplasm.
We report on a 34-year-old male who had abdominal discomfort with a large intraperitoneal mass.
Histological examination of the tumour biopsy revealed sheets of small round cells.
The cells were positive with vimentin and desmin (with occasional dot positivity) and negative for WT1 and CD 99 with immunohistochemistry.
Cytogenetics showed a translocation disrupting the EWSR 1 gene on 22 q 12 consistent with DSRCT.
Electron microscopic examination showed sparse cytoplasmic organelles.
The patient succumbed 34 months from disease presentation after multiple chemotherapies and thereafter radiotherapy.
In summary, our case exemplifies that it is crucial to combine clinical, histological, and molecular aspects in diagnosing DSRCT especially when characteristic dot positivity with desmin is weak along with deficient marking of WT1 and CD99 by immunohistochemistry.
Histology was also less clear than published examples of this entity with a poor desmoplastic response.
A multidisciplinary approach including early referral to specialised centres is recommended in these cases as tertiary referral centres will be required to substantiate the diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Angunawela, Preethika& Khalafallah, Alhossain A.& Wolfswinkel, Karen& Seaton, David& Brain, Terry. 2011. An Unusual Presentation of Desmoplastic Small Round Cell Tumour of the Abdomen : Morphological, Immunohistochemical, Ultrastructural, and Molecular Studies. Case Reports in Oncological Medicine،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-452645
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Angunawela, Preethika…[et al.]. An Unusual Presentation of Desmoplastic Small Round Cell Tumour of the Abdomen : Morphological, Immunohistochemical, Ultrastructural, and Molecular Studies. Case Reports in Oncological Medicine No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-452645
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Angunawela, Preethika& Khalafallah, Alhossain A.& Wolfswinkel, Karen& Seaton, David& Brain, Terry. An Unusual Presentation of Desmoplastic Small Round Cell Tumour of the Abdomen : Morphological, Immunohistochemical, Ultrastructural, and Molecular Studies. Case Reports in Oncological Medicine. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-452645
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452645
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر