Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells
المؤلفون المشاركون
Kim, Cy Hyun
Chung, Chung-Wook
Kim, Do Hyung
Jeong, Young-IL
Kang, Dae-Hwan
Kwak, Tae Won
Lee, Hye Myeong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate the effect of the combination of vorinostat and epigallocatechin-3-gallate against HuCC-T1 human cholangiocarcinoma cells.
A novel chemotherapy strategy is required as cholangiocarcinomas rarely respond to conventional chemotherapeutic agents.
Both vorinostat and EGCG induce apoptosis and suppress invasion, migration, and angiogenesis of tumor cells.
The combination of vorinostat and EGCG showed synergistic growth inhibitory effects and induced apoptosis in tumor cells.
The Bax/Bcl-2 expression ratio and caspase-3 and -7 activity increased, but poly (ADP-ribose) polymerase expression decreased when compared to treatment with each agent alone.
Furthermore, invasion, matrix metalloproteinase (MMP) expression, and migration of tumor cells decreased following treatment with the vorinostat and EGCG combination compared to those of vorinostat or EGCG alone.
Tube length and junction number of human umbilical vein endothelial cells (HUVECs) decreased as well as vascular endothelial growth factor expression following vorinostat and EGCG combined treatment.
These results indicate that the combination of vorinostat and EGCG had a synergistic effect on inhibiting tumor cell angiogenesis potential.
We suggest that the combination of vorinostat and EGCG is a novel option for cholangiocarcinoma chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kwak, Tae Won& Kim, Do Hyung& Chung, Chung-Wook& Lee, Hye Myeong& Kim, Cy Hyun& Jeong, Young-IL…[et al.]. 2013. Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-452746
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kwak, Tae Won…[et al.]. Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-452746
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kwak, Tae Won& Kim, Do Hyung& Chung, Chung-Wook& Lee, Hye Myeong& Kim, Cy Hyun& Jeong, Young-IL…[et al.]. Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-452746
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452746
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر