Urine from Sexually Mature Intact Male Mice Contributes to Increased Cardiovascular Responses during Free-Roaming and Restrained Conditions
المؤلفون المشاركون
Wilson, Justin L.
Lee, Dexter L.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Pheromones in the urine regulate aggression of male mice and castrated males produce less of these pheromones.
We tested the hypothesis that pheromones in the urine of sexually mature-intact (SMI) males placed in the cage bedding of an individually housed male mouse or in a mouse restrainer would contribute to a significant increase in mean arterial pressure (MAP), heart rate (HR), and activity.
Sexually mature male C57BL/6 mice were implanted with a biotelemetry transmitter to measure MAP, HR, and activity.
Urine (200 μL) from SMI mice placed in the cages of singularly housed male mice caused significant changes above baseline values for MAP (21±4 mmHg), HR (145±25 bpm), and activity (9±2 counts) when compared to urine from castrated mice-induced MAP (11±3 mmHg), HR (70±15 bpm), and activity (5±1 counts).
Pretreatment with terazosin significantly reduced the change in MAP (9±3 mmHg), heart rate (90±15 bpm), and activity (4±2 counts) responses to urine from SMI males.
Saline did not significantly increase MAP, HR, or activity in any group.
During restraint, urine from SMI mice caused a significant change in MAP (5±0.4 mmHg) and HR (17±1 bpm); urine from castrated mice did not cause a significant increase in MAP and HR.
Our results demonstrate that a significant increase in MAP, HR, and activity occurs when male mice are exposed to urine pheromones from SMI males.
In summary, pheromones in the urine of SMI male excreted in the cage bedding and mouse restrainers contribute to a significant increase in cardiovascular responses in the absence of direct physical contact with a different male mouse or animal handler.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Dexter L.& Wilson, Justin L.. 2012. Urine from Sexually Mature Intact Male Mice Contributes to Increased Cardiovascular Responses during Free-Roaming and Restrained Conditions. ISRN Veterinary Science،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-452778
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Dexter L.& Wilson, Justin L.. Urine from Sexually Mature Intact Male Mice Contributes to Increased Cardiovascular Responses during Free-Roaming and Restrained Conditions. ISRN Veterinary Science No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-452778
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Dexter L.& Wilson, Justin L.. Urine from Sexually Mature Intact Male Mice Contributes to Increased Cardiovascular Responses during Free-Roaming and Restrained Conditions. ISRN Veterinary Science. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-452778
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452778
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر