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Brazilian Green Propolis : Effects In Vitro and In Vivo on Trypanosoma cruzi
المؤلفون المشاركون
Souza, Eniuce Menezes de
de Castro, Solange Lisboa
Barbosa, Helene S.
Henriques-Pons, Andrea
Salomão, Kelly
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The composition of a Brazilian green propolis ethanolic extract (Et-Bra) and its effect on Trypanosoma cruzi trypomastigotes and other pathogenic microorganisms have already been reported.
Here, we further investigated Et-Bra targets in T.
cruzi and its effect on experimental infection of mice.
The IC50/4 days for inhibition of amastigote proliferation was 8.5 ± 1.8 μg mL−1, with no damage to the host cells.
In epimastigotes Et-Bra induced alterations in reservosomes, Golgi complex and mitochondrion.
These effects were confirmed by flow cytometry analysis.
In trypomastigotes, Et-Bra led to the loss of plasma membrane integrity.
The in vitro studies indicate that Et-Bra interferes in the functionality of the plasma membrane in trypomastigotes and of reservosomes and mitochondrion in epimastigotes.
Acutely infected mice were treated orally with Et-Bra and the parasitemia, mortality and GPT, GOT, CK and urea levels were monitored.
The extract (25–300 mg kg−1 body weight/day for 10 days) reduced the parasitemia, although not at significant levels; increased the survival of the animals and did not induce any hepatic, muscular lesion or renal toxicity.
Since Et-Bra was not toxic to the animals, it could be assayed in combination with other drugs.
Et-Bra could be a potential metacyclogenesis blocker, considering its effect on reservosomes, which are an important energy source during parasite differentiation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salomão, Kelly& Souza, Eniuce Menezes de& Henriques-Pons, Andrea& Barbosa, Helene S.& de Castro, Solange Lisboa. 2011. Brazilian Green Propolis : Effects In Vitro and In Vivo on Trypanosoma cruzi. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-452830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salomão, Kelly…[et al.]. Brazilian Green Propolis : Effects In Vitro and In Vivo on Trypanosoma cruzi. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-452830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salomão, Kelly& Souza, Eniuce Menezes de& Henriques-Pons, Andrea& Barbosa, Helene S.& de Castro, Solange Lisboa. Brazilian Green Propolis : Effects In Vitro and In Vivo on Trypanosoma cruzi. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-452830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-452830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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