Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis
المؤلفون المشاركون
Healy, Brian C.
Engler, David
Glanz, Bonnie
Chitnis, Tanuja
Musallam, Alexander
المصدر
Multiple Sclerosis International
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Sustained progression on the expanded disability status scale (EDSS) is a common outcome measure of disease progression in clinical studies of MS.
Unfortunately, this outcome may not accurately measure long-term and irreversible disease progression.
To assess the performance of definitions of sustained progression, patients with relapsing-remitting MS (RRMS) or a clinically isolated syndrome with evidence of lesions on a brain MRI were included in our study.
Fifteen definitions of sustained progression using both the EDSS and the functional system (FS) scales were investigated.
The impact of both relapses and changes in provider on the probability of maintaining progression was also evaluated.
Although the provider scoring the EDSS sometimes changed during followup, the provider had access to previous EDSS scores.
Between 15.8% and 42.2% of patients experienced sustained progression based on the definitions using EDSS as the outcome, but nearly 50% of these patients failed to maintain sustained progression for the duration of followup.
When FS scales were used, progression was most common on the pyramidal and sensory scales.
Unfortunately, progression on specific FS scales failed to be more sensitive to irreversible disability.
Relapses or changes in provider did not explain the poor performance of the measures.
Short-term changes in the EDSS or FS scores may not be an accurate marker of irreversible change in RRMS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Healy, Brian C.& Engler, David& Glanz, Bonnie& Musallam, Alexander& Chitnis, Tanuja. 2013. Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Healy, Brian C.…[et al.]. Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-453097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Healy, Brian C.& Engler, David& Glanz, Bonnie& Musallam, Alexander& Chitnis, Tanuja. Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-453097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر