Serum Levels of Gelatinase Associated Lipocalin as Indicator of the Inflammatory Status in Coronary Artery Disease
المؤلفون المشاركون
Zoubouloglou, Filitsa
Babalis, Dimitrios
Makris, Konstantinos
Spanou, Loukia
Demponeras, Christos
Kafkas, Nikolaos
المصدر
International Journal of Inflammation
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Atherosclerosis is a chronic inflammatory disease and the acute clinical manifestations represent acute on chronic inflammation.
Neutrophil gelatinase-associated lipocalin (NGAL) is found in the granules of human neutrophils, with many diverse functions.
The aim of this study was to evaluate the hypothesis that levels NGAL in blood may reflect the inflammatory process in various stages of coronary artery disease.
Methods.
We studied 140 patients, with SA 40, UA 35, NSTEMI 40, and STEMI 25, and 20 healthy controls.
Serum NGAL was measured upon admission and before coronary angiography.
Results.
Significant differences were observed in median serum-NGAL(ng/mL) between patients with SA (79.23 (IQR, 37.50–100.32)), when compared with UA (108.00 (68.34–177.59)), NSTEMI (166.49 (109.24–247.20)), and STEMI (178.63 (111.18–305.92)) patients and controls (50.31 (44.30–69.78)) with significant incremental value from SA to STEMI.
We observed a positive and significant correlation between serum-NGAL and hs-CRP (spearman coefficient rho = 0.685, P<0.0001) as well as with neutrophil counts (r = 0.511, P<0.0001).
Conclusions.
In patients with coronary artery disease serum levels of NGAL increase and reflect the degree of inflammatory process.
In patients with acute coronary syndromes, serum levels of NGAL have high negative predictive value and reflecting the inflammatory status could show the severity of coronary clinical syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kafkas, Nikolaos& Demponeras, Christos& Zoubouloglou, Filitsa& Spanou, Loukia& Babalis, Dimitrios& Makris, Konstantinos. 2012. Serum Levels of Gelatinase Associated Lipocalin as Indicator of the Inflammatory Status in Coronary Artery Disease. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453112
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kafkas, Nikolaos…[et al.]. Serum Levels of Gelatinase Associated Lipocalin as Indicator of the Inflammatory Status in Coronary Artery Disease. International Journal of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-453112
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kafkas, Nikolaos& Demponeras, Christos& Zoubouloglou, Filitsa& Spanou, Loukia& Babalis, Dimitrios& Makris, Konstantinos. Serum Levels of Gelatinase Associated Lipocalin as Indicator of the Inflammatory Status in Coronary Artery Disease. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453112
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453112
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر