Mebeverine for Pediatric Functional Abdominal Pain : A Randomized, Placebo-Controlled Trial
المؤلفون المشاركون
Pourmoghaddas, Zahra
Gholamrezaei, Ali
Saneian, Hossein
Roohafza, Hamidreza
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
We evaluated the effectiveness of an antispasmodic, mebeverine, in the treatment of childhood functional abdominal pain (FAP).
Children with FAP (n = 115, aged 6–18 years) received mebeverine (135 mg, twice daily) or placebo for 4 weeks.
Response was defined as ≥2 point reduction in the 6-point pain scale or “no pain.” Physician-rated global severity was also evaluated.
Patients were followed up for 12 weeks.
Eighty-seven patients completed the trial (44 with mebeverine).
Per-protocol and intention-to-treat (ITT) analyses were conducted.
Treatment response rate in the mebeverine and placebo groups based on per-protocol [ITT] analysis was 54.5% [40.6%] and 39.5% [30.3%] at week 4 (P = 0.117 [0.469]) and 72.7% [54.2%] and 53.4% [41.0] at week 12, respectively (P = 0.0503 [0.416]).
There was no significant difference between the two groups in change of the physician-rated global severity score after 4 weeks (P = 0.723) or after 12 weeks (P = 0.870) in per-protocol analysis; the same results were obtained in ITT analysis.
Mebeverine seems to be effective in the treatment of childhood FAP, but our study was not able to show its statistically significant effect over placebo.
Further trials with larger sample of patients are warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pourmoghaddas, Zahra& Saneian, Hossein& Roohafza, Hamidreza& Gholamrezaei, Ali. 2014. Mebeverine for Pediatric Functional Abdominal Pain : A Randomized, Placebo-Controlled Trial. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-453208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pourmoghaddas, Zahra…[et al.]. Mebeverine for Pediatric Functional Abdominal Pain : A Randomized, Placebo-Controlled Trial. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-453208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pourmoghaddas, Zahra& Saneian, Hossein& Roohafza, Hamidreza& Gholamrezaei, Ali. Mebeverine for Pediatric Functional Abdominal Pain : A Randomized, Placebo-Controlled Trial. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-453208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر