Constrained Network Modularity
المؤلف
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Static representations of protein interactions networks or PIN reflect measurements referred to a variety of conditions, including time.
To partially bypass such limitation, gene expression information is usually integrated in the network to measure its “activity level.” In general, the entire PIN modular organization (complexes, pathways) can reveal changes of configuration whose functional significance depends on biological annotation.
However, since network dynamics are based on the presence of different conditions leading to comparisons between normal and disease states, or between networks observed sequentially in time, our working hypothesis refers to the analysis of differential networks based on varying modularity and uncertainty.
Two popular methods were applied and evaluated, k-core and Q-modularity, over a reference yeast dataset comprising a PIN of literature-curated data obtained from the fusion of heterogeneous measurements sources.
While the functional aspect of interest is cell cycle and the corresponding interactions were isolated, the PIN dynamics were externally induced by time-course measured gene expression values, which we consider one of the “modularity drivers.” Notably, due to the nature of such expression values referred to the “just-in-time method,” we could specialize our approach according to three constrained modular configurations then comparatively assessed through local entropy measures.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Capobianco, Enrico. 2012. Constrained Network Modularity. ISRN Biomathematics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453279
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Capobianco, Enrico. Constrained Network Modularity. ISRN Biomathematics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-453279
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Capobianco, Enrico. Constrained Network Modularity. ISRN Biomathematics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453279
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453279
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر