Three Metachronous Osteosarcomas within 22 Years without Pulmonary Metastases : A Case Report and Review of the Literature
المؤلفون المشاركون
Rabitsch, Katharina
Leithner, Andreas
Friesenbichler, Joerg
Pirker-Frühauf, Ulrike Michaela
Windhager, Reinhard
Bauernhofer, Thomas
Liegl-Atzwanger, Bernadette
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-25
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Introduction.
We present the extremely rare case of a patient with three metachronous osteosarcomas within 22 years without evident pulmonary manifestation of disease 30 years after first diagnosis.
Case Presentation.
In 1983, a high-grade osteosarcoma of the left distal femur was diagnosed in an 18-year-old Caucasian male.
He received rotationplasty accompanied by pre- and postoperative chemotherapy.
Ten years later, an osteoblastic osteosarcoma occurred in TH12.
En bloc resection and pre- and postoperative chemotherapy followed.
In 2005, the patient developed another high-grade osteosarcoma in his right distal femur.
Treatment included a wide resection and reconstruction with a tumour endoprosthesis as well as (neo)adjuvant chemotherapy.
After the third tumour occurrence, cytogenetic and molecular genetic examinations (p53, rb1) were performed, showing a normal genetic pattern.
Screening for metastases never showed clinical evidence of extraskeletal tumour manifestation.
Discussion.
In patients presenting metachronous osteosarcoma, identification of their lesions clonality (second primary tumour or metastases) could lead to a better understanding of tumour development and help to filter patients who need extended long-term followup due to a higher risk of late occurring sarcoma recurrence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pirker-Frühauf, Ulrike Michaela& Friesenbichler, Joerg& Rabitsch, Katharina& Liegl-Atzwanger, Bernadette& Bauernhofer, Thomas& Windhager, Reinhard…[et al.]. 2013. Three Metachronous Osteosarcomas within 22 Years without Pulmonary Metastases : A Case Report and Review of the Literature. Case Reports in Orthopedics،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-453773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pirker-Frühauf, Ulrike Michaela…[et al.]. Three Metachronous Osteosarcomas within 22 Years without Pulmonary Metastases : A Case Report and Review of the Literature. Case Reports in Orthopedics No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-453773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pirker-Frühauf, Ulrike Michaela& Friesenbichler, Joerg& Rabitsch, Katharina& Liegl-Atzwanger, Bernadette& Bauernhofer, Thomas& Windhager, Reinhard…[et al.]. Three Metachronous Osteosarcomas within 22 Years without Pulmonary Metastases : A Case Report and Review of the Literature. Case Reports in Orthopedics. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-453773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر