Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver
المؤلفون المشاركون
Yanagiba, Yukie
Ito, Yuki
Nakamura, Toshiki
Ramdhan, Doni Hikmat
Yamagishi, Nozomi
Kamijima, Michihiro
Gonzalez, Frank J.
Naito, Hisao
Nakajima, Tamie
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Dibutylphthalate (DBP), di(2-ethylhexyl)phthalate (DEHP), and di(2-ethylhexyl)adipate (DEHA) are used as plasticizers.
Their metabolites activate peroxisome proliferator-activated receptor (PPAR) α, which may be related to their toxicities.
However, species differences in the receptor functions between rodents and human make it difficult to precisely extrapolate their toxicity from animal studies to human.
In this paper, we compared the species differences in the activation of mouse and human hepatic PPARα by these plasticizers using wild-type (mPPARα) and humanized PPARα (hPPARα) mice.
At 12 weeks old, each genotyped male mouse was classified into three groups, and fed daily for 2 weeks per os with corn oil (vehicle control), 2.5 or 5.0 mmol/kg DBP (696, 1392 mg/kg), DEHP (977, 1953 mg/kg), and DEHA (926, 1853 mg/kg), respectively.
Generally, hepatic PPARα of mPPARα mice was more strongly activated than that of hPPARα mice when several target genes involving β-oxidation of fatty acids were evaluated.
Interestingly, all plasticizers also activated hepatic constitutive androstane receptor (CAR) more in hPPARα mice than in mPPARα mice.
Taken together, these plasticizers activated mouse and human hepatic PPARα as well as CAR.
The activation of PPARα was stronger in mPPARα mice than in hPPARα mice, while the opposite was true of CAR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ito, Yuki& Nakamura, Toshiki& Yanagiba, Yukie& Ramdhan, Doni Hikmat& Yamagishi, Nozomi& Naito, Hisao…[et al.]. 2012. Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver. PPAR Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-453968
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ito, Yuki…[et al.]. Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver. PPAR Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-453968
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ito, Yuki& Nakamura, Toshiki& Yanagiba, Yukie& Ramdhan, Doni Hikmat& Yamagishi, Nozomi& Naito, Hisao…[et al.]. Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-453968
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-453968
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر