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Pathogen-Driven Selection in the Human Genome
المؤلفون المشاركون
Sironi, Manuela
Cagliani, Rachele
المصدر
International Journal of Evolutionary Biology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Infectious diseases and epidemics have always accompanied and characterized human history, representing one of the main causes of death.
Even today, despite progress in sanitation and medical research, infections are estimated to account for about 15% of deaths.
The hypothesis whereby infectious diseases have been acting as a powerful selective pressure was formulated long ago, but it was not until the availability of large-scale genetic data and the development of novel methods to study molecular evolution that we could assess how pervasively infectious agents have shaped human genetic diversity.
Indeed, recent evidences indicated that among the diverse environmental factors that acted as selective pressures during the evolution of our species, pathogen load had the strongest influence.
Beside the textbook example of the major histocompatibility complex, selection signatures left by pathogen-exerted pressure can be identified at several human loci, including genes not directly involved in immune response.
In the future, high-throughput technologies and the availability of genetic data from different populations are likely to provide novel insights into the evolutionary relationships between the human host and its pathogens.
Hopefully, this will help identify the genetic determinants modulating the susceptibility to infectious diseases and will translate into new treatment strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cagliani, Rachele& Sironi, Manuela. 2013. Pathogen-Driven Selection in the Human Genome. International Journal of Evolutionary Biology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-454234
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cagliani, Rachele& Sironi, Manuela. Pathogen-Driven Selection in the Human Genome. International Journal of Evolutionary Biology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-454234
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cagliani, Rachele& Sironi, Manuela. Pathogen-Driven Selection in the Human Genome. International Journal of Evolutionary Biology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-454234
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454234
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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