Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy
المؤلفون المشاركون
Tseng, Chiao-Shih
Chen, Shih-Ming
Hsu, Kuang-Yang
Chien, Shu-Chen
المصدر
Advances in Pharmacological Sciences
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli.
To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and inulin, New Zealand white rabbits were used in this study.
The plasma concentrations of PAH and inulin were determined by validated HPLC methods.
After a single intravenous administration of 0.5 mg/kg aristolochic acid sodium (AANa), rabbits exhibited mild to moderate nephrotoxicity on the 7th day.
Significant tubulointerstitial damage to kidney specimens was found, but there were no remarkable glomerular changes.
Clearance rates of PAH and inulin both significantly decreased in AANa-treated rabbits.
In addition, there was a significant correlation among the degree of tubulointerstitial changes and PK parameters of PAH after AANa administration, but no correlation was noted with the PKs of inulin.
With mild to moderate AAN in rabbits, the renal plasma flow significantly decreased by 55%, and the glomerular filtration rate also significantly decreased by 85%.
In conclusion, major renal lesions were found on proximal tubules after AANa administration.
The PKs of PAH and inulin significantly changed, and kidney functions, including the RPF and GFR, were reduced.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tseng, Chiao-Shih& Chen, Shih-Ming& Chien, Shu-Chen& Hsu, Kuang-Yang. 2011. Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tseng, Chiao-Shih…[et al.]. Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-454246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tseng, Chiao-Shih& Chen, Shih-Ming& Chien, Shu-Chen& Hsu, Kuang-Yang. Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر