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Enzyme Histochemical Assessment of Mitochondrial Functions in Patients with Myopathic form of Limb-Girdle Syndrome
المؤلفون المشاركون
Paliwal, Vimal Kumar
Pal, Lily
Verma, Ritu
Pandey, Rakesh
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Isolated mitochondrial myopathy is characterized by slowly progressive limb-girdle muscle weakness and resembles other muscle disorders like muscular dystrophy or inflammatory myopathy on clinical grounds.
Identification of abnormal mitochondria in the muscle tissue is required for the diagnosis of isolated mitochondrial myopathy.
Therefore, this study was done with aim to identify patients with isolated mitochondrial myopathy among those with limb-girdle muscle syndromes of undefined cause.
Forty-eight consecutive patients with limb-girdle muscle disease from 2008 to 2010 were screened for Duchenne/Becker muscular dystrophy gene deletion, metabolic myopathy, and drug-induced and endocrine causes.
Twenty patients without an identifiable cause were subjected to muscle biopsy for hematoxylin and eosin staining and enzyme histochemistry.
Clinical, biochemical, and electrophysiological features in all these patients with limb-girdle muscle disease were nonspecific, and no conclusion regarding the underlying cause could be drawn from these investigations.
On hematoxylin and eosin staining, 12 patients were diagnosed as muscular dystrophy, inflammatory myopathy with characteristic appearance of polymyositis was diagnosed in 4 patients, and 3 patients had normal muscle histology.
After enzyme histochemistry, one patient was identified having mitochondrial myopathy.
A brief case summary of the only patient diagnosed as isolated mitochondrial myopathy in our study is presented.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Verma, Ritu& Pal, Lily& Pandey, Rakesh& Paliwal, Vimal Kumar. 2011. Enzyme Histochemical Assessment of Mitochondrial Functions in Patients with Myopathic form of Limb-Girdle Syndrome. ISRN Pathology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-454295
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Verma, Ritu…[et al.]. Enzyme Histochemical Assessment of Mitochondrial Functions in Patients with Myopathic form of Limb-Girdle Syndrome. ISRN Pathology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-454295
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Verma, Ritu& Pal, Lily& Pandey, Rakesh& Paliwal, Vimal Kumar. Enzyme Histochemical Assessment of Mitochondrial Functions in Patients with Myopathic form of Limb-Girdle Syndrome. ISRN Pathology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-454295
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454295
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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