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Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye
المؤلفون المشاركون
Fukuda, Masahide
Tsukahara, Yasutomo
Honda, Shigeru
Kusuhara, Sentaro
Kondo, Naoshi
Nagai, Takayuki
Negi, Akira
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-07-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM).
Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported to have anti-angiogenic effects.
The purpose of this study is to investigate the therapeutic effects of oral bisphosphonates for CNV in humans.
Methods.
Thirty-six consecutive cases with CNV due to AMD or PM who declined anti-VEGF therapy were recruited.
The patients were prescribed 5 mg of oral alendronates daily for 6 months.
The best-corrected visual-acuity (BCVA), the lesion size in fundus photographs and fluorescein angiography, foveal thickness and total macular volume in optical coherence tomography were compared between pre- and post-treatment.
Results.
The mean BCVA of the patients was significantly improved after a months with the treatment in the AMD group.
In the PM group, the mean BCVA was maintained up to 6 months with the treatment.
The mean lesion size was significantly decreased by 3 months in both groups.
The averages of foveal thickness and total macular volume were significantly reduced after 1 month of treatment in the AMD group.Conclusions.
Oral bisphosphonate should be further investigated as a possible therapeutic and preventive drug for CNV due to AMD and PM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Honda, Shigeru& Nagai, Takayuki& Kondo, Naoshi& Fukuda, Masahide& Kusuhara, Sentaro& Tsukahara, Yasutomo…[et al.]. 2010. Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye. Journal of Ophthalmology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-454486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Honda, Shigeru…[et al.]. Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye. Journal of Ophthalmology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-454486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Honda, Shigeru& Nagai, Takayuki& Kondo, Naoshi& Fukuda, Masahide& Kusuhara, Sentaro& Tsukahara, Yasutomo…[et al.]. Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye. Journal of Ophthalmology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-454486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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