Effects of Flos carthami on CYP2D6 and on the Pharmacokinetics of Metoprolol in Rats
المؤلفون المشاركون
Liu, Yan
Liu, Rui
Liu, Gaofeng
Zhang, Zhiren
Dong, Feng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-11-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Flos carthami is a traditional Chinese herbal medicine.
Clinically, the Flos carthami Injection has been used concomitantly with other Western drugs and may be used concomitantly with β-blockers, such as metoprolol, to treat cerebrovascular and coronary heart diseases, in China.
Metoprolol is a CYP2D6 substrate and is predominantly metabolized by this isozyme.
However, we do not know whether there is an effect of Flos carthami on CYP2D6 and the consequences of such an effect.
Concern is raised regarding the possible herb-drug interaction.
In this report, the effects of Flos carthami on the activity of CYP2D6 in vivo and in vitro and on the pharmacokinetics of metoprolol, in rats, are investigated.
To assess the inhibitory potency of Flos carthami, the concentration associated with 50% inhibition (IC50) of dextromethorphan metabolism was determined based on the concentration-inhibition curves.
The inhibitory effect of Flos carthami on CYP2D6 was also compared with cimetidine in vitro.
Flos carthami could significantly inhibit CYP2D6 in rats both in vitro and in vivo (P<.05) and could slow down the metabolic rate of metoprolol as suggested by prolonged t1/2 (67.45%), by increased Cmax (74.51%) and AUC0−∞ (76.89%).
These results suggest that CYP2D6 is a risk factor when Flos carthami is administered concomitantly with metoprolol or other CYP2D6 substrates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Gaofeng& Liu, Yan& Liu, Rui& Dong, Feng& Zhang, Zhiren. 2010. Effects of Flos carthami on CYP2D6 and on the Pharmacokinetics of Metoprolol in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Gaofeng…[et al.]. Effects of Flos carthami on CYP2D6 and on the Pharmacokinetics of Metoprolol in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-454515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Gaofeng& Liu, Yan& Liu, Rui& Dong, Feng& Zhang, Zhiren. Effects of Flos carthami on CYP2D6 and on the Pharmacokinetics of Metoprolol in Rats. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر