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Progesterone Attenuates Experimental Subarachnoid Hemorrhage-Induced Vasospasm by Upregulation of Endothelial Nitric Oxide Synthase via Akt Signaling Pathway
المؤلفون المشاركون
Lin, Chih-Lung
Tsai, Yee-Jean
Chang, Chih-Zen
Chang, Chia-Mao
Su, Yu-Feng
Loh, Joon-Khim
Chung, Chia-Li
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Cerebral vasospasm is the leading cause of mortality and morbidity in patients after aneurysmal subarachnoid hemorrhage (SAH).
However, the mechanism and adequate treatment of vasospasm are still elusive.
In the present study, we evaluate the effect and possible mechanism of progesterone on SAH-induced vasospasm in a two-hemorrhage rodent model of SAH.
Progesterone (8 mg/kg) was subcutaneously injected in ovariectomized female Sprague-Dawley rats one hour after SAH induction.
The degree of vasospasm was determined by averaging the cross-sectional areas of basilar artery 7 days after first SAH.
Expressions of endothelial nitric oxide synthase (eNOS) and phosphorylated Akt (phospho-Akt) in basilar arteries were evaluated.
Prior to perfusion fixation, there were no significant differences among the control and treated groups in physiological parameters recorded.
Progesterone treatment significantly (P<0.01) attenuated SAH-induced vasospasm.
The SAH-induced suppression of eNOS protein and phospho-Akt were relieved by progesterone treatment.
This result further confirmed that progesterone is effective in preventing SAH-induced vasospasm.
The beneficial effect of progesterone might be in part related to upregulation of expression of eNOS via Akt signaling pathway after SAH.
Progesterone holds therapeutic promise in the treatment of cerebral vasospasm following SAH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Chia-Mao& Su, Yu-Feng& Chang, Chih-Zen& Chung, Chia-Li& Tsai, Yee-Jean& Loh, Joon-Khim…[et al.]. 2014. Progesterone Attenuates Experimental Subarachnoid Hemorrhage-Induced Vasospasm by Upregulation of Endothelial Nitric Oxide Synthase via Akt Signaling Pathway. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-454576
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Chia-Mao…[et al.]. Progesterone Attenuates Experimental Subarachnoid Hemorrhage-Induced Vasospasm by Upregulation of Endothelial Nitric Oxide Synthase via Akt Signaling Pathway. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-454576
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Chia-Mao& Su, Yu-Feng& Chang, Chih-Zen& Chung, Chia-Li& Tsai, Yee-Jean& Loh, Joon-Khim…[et al.]. Progesterone Attenuates Experimental Subarachnoid Hemorrhage-Induced Vasospasm by Upregulation of Endothelial Nitric Oxide Synthase via Akt Signaling Pathway. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-454576
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454576
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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