Fatal Lactic Acidosis in a Kidney Transplant Recipient on Combination Antiretroviral Therapy after Initiation of Tacrolimus Therapy
المؤلفون المشاركون
Hilton, Rachel
Wong, Terry
Lucas, Sebastian B.
Kulasegaram, Ranjababu
Holmes, Michael V.
المصدر
Case Reports in Transplantation
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In general, kidney transplantation is safe and efficacious in patients receiving treatment for HIV.
Although multiple drug interactions between antiviral and immunosuppressive treatments exist, few patients experience serious adverse reactions.
We report a case of fatal lactic acidosis in a healthy kidney transplant recipient with stable HIV infection who had previously received treatment for and cleared hepatitis C virus infection.
Death occurred less than one month following the initiation of tacrolimus therapy.
Based on predicted drug interactions, appropriate tacrolimus dosing was calculated prior to its commencement, yet plasma tacrolimus levels were initially unexpectedly high.
The patient subsequently developed lactic acidosis and hepatic steatosis, presumably due to mitochondrial toxicity from the antiretroviral regimen on which he had previously been stable.
We suspect CYP2C19*2 (poor metaboliser) genotype status and concomitant treatment with lansoprazole, tacrolimus, and antiretroviral (ARV) medications resulted in hepatic decompensation.
This highlights the importance of careful interaction screening for all new drugs administered to patients with HIV who have complex treatment regimens as well as heightened clinical vigilance for unexpected toxicities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Holmes, Michael V.& Kulasegaram, Ranjababu& Lucas, Sebastian B.& Wong, Terry& Hilton, Rachel. 2012. Fatal Lactic Acidosis in a Kidney Transplant Recipient on Combination Antiretroviral Therapy after Initiation of Tacrolimus Therapy. Case Reports in Transplantation،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-454812
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holmes, Michael V.…[et al.]. Fatal Lactic Acidosis in a Kidney Transplant Recipient on Combination Antiretroviral Therapy after Initiation of Tacrolimus Therapy. Case Reports in Transplantation No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-454812
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Holmes, Michael V.& Kulasegaram, Ranjababu& Lucas, Sebastian B.& Wong, Terry& Hilton, Rachel. Fatal Lactic Acidosis in a Kidney Transplant Recipient on Combination Antiretroviral Therapy after Initiation of Tacrolimus Therapy. Case Reports in Transplantation. 2012. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-454812
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454812
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر