Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hrhr Rats
المؤلفون المشاركون
López-Fontana, Constanza M.
Hapon, María B.
Pistone-Creydt, Virginia
Jahn, Graciela A.
Santiano, Flavia E.
Ezquer, Marcelo E.
Carón, Rubén W.
Sasso, Corina V.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Prolactin (PRL) is a key player in the development of mammary cancer.
We studied the effects of parity or hyperprolactinemia on mammary carcinogenesis in OFA hr/hr treated with 7,12-dimethylbenzanthracene.
They were divided into three groups: nulliparous (Null), primiparous (PL, after pregnancy and lactation), and hyperprolactinemic rats (I, implanted in the arcuate nucleus with 17β-estradiol).
The tumor incidence was similar in the three groups.
However, a higher percentage of regressing tumors was evident in the PL group.
Serum PRL, mammary development, and mammary β-casein content were higher in I rats compared to Null.
The expression of hormone receptors was similar in the different groups.
However, mammary tissue from PL rats bearing tumors had increased expression of PRL and estrogen alpha receptors compared to rats free of tumors.
Our results suggest that serum PRL levels do not have relevance on the incidence of tumors, probably because the low levels of PRL in OFA rats are not further decreased by PL like in other strains.
However, supraphysiological levels of PRL affect carcinogenesis.
PL induces regression of the tumors due to the differentiation produced on the mammary cells.
Alterations in the expression of hormonal receptors may be involved in progression and regression of tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sasso, Corina V.& Santiano, Flavia E.& López-Fontana, Constanza M.& Pistone-Creydt, Virginia& Ezquer, Marcelo E.& Hapon, María B.…[et al.]. 2014. Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hrhr Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-454837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sasso, Corina V.…[et al.]. Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hrhr Rats. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-454837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sasso, Corina V.& Santiano, Flavia E.& López-Fontana, Constanza M.& Pistone-Creydt, Virginia& Ezquer, Marcelo E.& Hapon, María B.…[et al.]. Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hrhr Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-454837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر