Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease
المؤلفون المشاركون
Austin, Wesley F.
Bronk, Brian S.
McKee, Timothy D.
Hubbs, Jed L.
Ives, Jeff
Loureiro, Robyn M. B.
Jonker, Jeff
Fuller, Nathan O.
Dumin, Jo Ann
Xia, Weiming
Shen, Ruichao
Tate, Barbara
Pojasek, Kevin
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)—formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline—are triggered by Aβ peptide dysregulation (Kakuda et al., 2006, Sato et al., 2003, Qi-Takahara et al., 2005).
Since γ-secretase is critical for Aβ production, many in the biopharmaceutical community focused on γ-secretase as a target for therapeutic approaches for Alzheimer's disease.
However, pharmacological approaches to control γ-secretase activity are challenging because the enzyme has multiple, physiologically critical protein substrates.
To lower amyloidogenic Aβ peptides without affecting other γ-secretase substrates, the epsilon (ε) cleavage that is essential for the activity of many substrates must be preserved.
Small molecule modulators of γ-secretase activity have been discovered that spare the ε cleavage of APP and other substrates while decreasing the production of Aβ42.
Multiple chemical classes of γ-secretase modulators have been identified which differ in the pattern of Aβ peptides produced.
Ideally, modulators will allow the ε cleavage of all substrates while shifting APP cleavage from Aβ42 and other highly amyloidogenic Aβ peptides to shorter and less neurotoxic forms of the peptides without altering the total Aβ pool.
Here, we compare chemically distinct modulators for effects on APP processing and in vivo activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tate, Barbara& McKee, Timothy D.& Loureiro, Robyn M. B.& Dumin, Jo Ann& Xia, Weiming& Pojasek, Kevin…[et al.]. 2012. Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-454868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tate, Barbara…[et al.]. Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-454868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tate, Barbara& McKee, Timothy D.& Loureiro, Robyn M. B.& Dumin, Jo Ann& Xia, Weiming& Pojasek, Kevin…[et al.]. Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-454868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر