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Alzheimer’s Disease Dementia as the Diagnosis Best Supported by the Cerebrospinal Fluid Biomarkers : Difference in Cut-Off Levels from Thai Experience
المؤلفون المشاركون
Udomphanthurak, S.
Washirutmangkur, L.
Senanarong, V.
Aoonkaew, N.
Ratanabunakit, C.
Siwasariyanon, N.
Poungvarin, N.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-16
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
To determine how beta-amyloid 1-42 (Aβ 1-42), total tau (tTau), and phosphorylated tau (pTau) levels in CSF behave in a cohort of Thai patients from the Memory Clinic in Bangkok, Thailand.
Methods.
During 2009–2011, twenty eight subjects from the memory clinic at Siriraj Hospital had CSF analysis for AD biomarkers.
Aβ 1-42, tTau, and pTau (at amino acid 181) were measured in CSF by ELISA technique.
Results.
Mean of Thai mental state examination (TMSE) of 28 Thai cohort was 16.48 (6.63).
Fourteen had AD, ten had non-AD dementia, and four non-cases were those with subjective memory complaint (SMC) without dementia.
Mean CSF Aβ 1-42, tTau, ptau (181), and pTau/Aβ 1-42 in the AD group were 241.36 (60.14) pg/mL, 222.79 (212.24) pg/mL, 40.79 (27.84) pg/mL, and 0.18 (0.12) accordingly.
Mean CSF Aβ 1-42, tTau, pTau (181), and pTau/Aβ 1-42 in the non-AD dementia group were 430.40 (125.18) pg/mL, 349.30 (692.16) pg/mL, 36.80 (14.90) pg/mL, and 0.09 (0.04) accordingly.
Mean CSF Aβ 1-42, tTau, pTau (181), and pTau/Aβ 1-42 in the non-cases with SMC without dementia were 499.75 (93.44) pg/mL, 137.25 (62.74) pg/mL, 31.75 (17.48) pg/mL, and 0.06 (0.02).
There is significant difference (P<0.05) among the 3 groups in CSF Aβ 1-42 and pTau/Aβ 1-42.
We propose mean + 1.5 SD of CSF Aβ 1-42 in AD group (331.57 pg/mL) to be the cut-off point in Thai subjects.
Conclusion.
There are significant different in CSF Aβ 1-42 and CSF p-tau/Aβ 1-42 among those with AD, non-AD dementia and non cases with SMC without dementia in Thai cohort.
Cut-off point of CSF Aβ 1-42 of 331.57 pg/mL is suggested in Thai study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Senanarong, V.& Siwasariyanon, N.& Washirutmangkur, L.& Poungvarin, N.& Ratanabunakit, C.& Aoonkaew, N.…[et al.]. 2012. Alzheimer’s Disease Dementia as the Diagnosis Best Supported by the Cerebrospinal Fluid Biomarkers : Difference in Cut-Off Levels from Thai Experience. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-454896
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Senanarong, V.…[et al.]. Alzheimer’s Disease Dementia as the Diagnosis Best Supported by the Cerebrospinal Fluid Biomarkers : Difference in Cut-Off Levels from Thai Experience. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-454896
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Senanarong, V.& Siwasariyanon, N.& Washirutmangkur, L.& Poungvarin, N.& Ratanabunakit, C.& Aoonkaew, N.…[et al.]. Alzheimer’s Disease Dementia as the Diagnosis Best Supported by the Cerebrospinal Fluid Biomarkers : Difference in Cut-Off Levels from Thai Experience. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-454896
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454896
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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