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Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer
المؤلفون المشاركون
Song, Bo
Wang, Shuchun
Zhang, Dianliang
Wang, Xinxiang
Zheng, Hongmei
المصدر
Comparative and Functional Genomics
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-11-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Interleukin (IL)-8 has been implicated in the development of cancer cachexia.
The polymorphism of IL-8 gene, which may affect the production level of IL-8, may be associated with cancer cachexia.
Methods.
The serum IL-8 level in our study was examined by radioimmunoassay.
We also analyzed single nucleotide polymorphisms (SNPs) −251 A/T and +781 C/T of IL-8 gene, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results.
The serum levels of IL-8 were significantly elevated in patients with low-third gastric cancer compared with controls, and were further up-regulated in patients with cachexia than those without (Z=−3.134, P=.002).
A significantly increased frequency of +781 T allele was noted in patients with cachexia (OR=2.247, 95% CI: 1.351–3.737, P=.002).
The +781 TT genotype was observed to be associated with a significantly increased risk of cachexia (OR=3.167, 95% CI: 1.265–7.929, P=.011), and with odds ratio of 3.033 (95% CI: 1.065–8.639, P=.038) for cachexia after adjusting for potential confounding factors.
Meanwhile, haplotype analysis indicated a borderline positive association between T251T781 haplotype and cachexia as compared with the T251C781 haplotype (OR=4.92, 95% CI: 1.00–24.28; ,P=.053).
Conclusions.
IL-8 appears to be associated with cachexia from patients with low-third gastric cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Bo& Zhang, Dianliang& Wang, Shuchun& Zheng, Hongmei& Wang, Xinxiang. 2009. Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer. Comparative and Functional Genomics،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-454913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Bo…[et al.]. Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer. Comparative and Functional Genomics No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-454913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Bo& Zhang, Dianliang& Wang, Shuchun& Zheng, Hongmei& Wang, Xinxiang. Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer. Comparative and Functional Genomics. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-454913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-454913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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