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Acetaldehyde-Mediated Neurotoxicity : Relevance to Fetal Alcohol Spectrum Disorders
المؤلفون المشاركون
de la Monte, Suzanne M.
Longato, Lisa
Nguyen, Quynh-GiaoLy
Tong, Ming
Spaisman, Amy
Chen, William C.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Ethanol-induced neuro-developmental abnormalities are associated with impaired insulin and IGF signaling, and increased oxidative stress in CNS neurons.
We examined the roles of ethanol and its principal toxic metabolite, acetaldehyde, as mediators of impaired insulin/IGF signaling and oxidative injury in immature cerebellar neurons.
Cultures were exposed to 3.5 mM acetaldehyde or 50 mM ethanol ± 4-methylpyrazole (4-MP), an inhibitor of ethanol metabolism, and viability, mitochondrial function, oxidative stress, DNA damage, and insulin responsiveness were measured 48 hours later.
Acetaldehyde or ethanol increased neuronal death and levels of 8-OHdG and 4-HNE, and reduced mitochondrial function.
Ethanol inhibited insulin responsiveness, whereas acetaldehyde did not.
4-MP abated ethanol-induced oxidative stress and mitochondrial dysfunction, but failed to restore insulin responsiveness.
Furthermore, alcohol and aldehyde metabolizing enzyme genes were inhibited by prenatal ethanol exposure; this effect was mediated by acetaldehyde and not ethanol + 4MP.
These findings suggest that brain insulin resistance in prenatal alcohol exposure is caused by direct effects of ethanol, whereas oxidative stress induced neuronal injury is likely mediated by ethanol and its toxic metabolites.
Moreover, the adverse effects of prenatal ethanol exposure on brain development may be exacerbated by down-regulation of genes needed for metabolism and detoxification of alcohol in the brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tong, Ming& Longato, Lisa& Nguyen, Quynh-GiaoLy& Chen, William C.& Spaisman, Amy& de la Monte, Suzanne M.. 2011. Acetaldehyde-Mediated Neurotoxicity : Relevance to Fetal Alcohol Spectrum Disorders. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-455000
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tong, Ming…[et al.]. Acetaldehyde-Mediated Neurotoxicity : Relevance to Fetal Alcohol Spectrum Disorders. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-455000
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tong, Ming& Longato, Lisa& Nguyen, Quynh-GiaoLy& Chen, William C.& Spaisman, Amy& de la Monte, Suzanne M.. Acetaldehyde-Mediated Neurotoxicity : Relevance to Fetal Alcohol Spectrum Disorders. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-455000
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455000
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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