Probiotics, Symptoms, and Gut Microbiota : What Are the Relations? A Randomized Controlled Trial in Subjects with Irritable Bowel Syndrome
المؤلفون المشاركون
Farup, Per G.
Ligaarden, Solveig C.
Jacobsen, Morten B.
Rudi, Knut
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Knowledge of the mechanism of action of probiotics in subjects with irritable bowel syndrome (IBS) is imperfect.
Objective.
This trial aimed at discriminating between a direct effect on the gut wall and an indirect effect caused by modulation of the fecal microbiota.
Design.
Randomized, double-blind, crossover trial.
Material and Methods.
Patients with IBS were given one capsule of 1010 CFU L.
plantarum MF 1298 or placebo once daily.
Symptoms were registered (score 0–15) and feces collected at the end of each period.
The gut microbiota was analyzed with 16S rRNA gene analyses and results reported as proportions of Bacteroides, Faecalibacterium, and Lachnospiraceae and Simpson’s D diversity score.
Results.
Sixteen participants (11 women) with a mean age of 50 years (SD 11) were available for the analyses.
Intake of L.
plantarum MF 1298 was associated with a significant aggravation of symptoms, but neither intake of L.
plantarum MF 1298 nor symptoms were associated with the composition of the fecal microbiota (P values >0.10).
Conclusions.
The trial indicates that the symptomatic aggravation related to intake of L.
plantarum MF 1298 was a direct effect of the microbe on the gut wall and not caused by changes in the fecal microbiota.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Farup, Per G.& Jacobsen, Morten B.& Ligaarden, Solveig C.& Rudi, Knut. 2012. Probiotics, Symptoms, and Gut Microbiota : What Are the Relations? A Randomized Controlled Trial in Subjects with Irritable Bowel Syndrome. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455083
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Farup, Per G.…[et al.]. Probiotics, Symptoms, and Gut Microbiota : What Are the Relations? A Randomized Controlled Trial in Subjects with Irritable Bowel Syndrome. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-455083
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Farup, Per G.& Jacobsen, Morten B.& Ligaarden, Solveig C.& Rudi, Knut. Probiotics, Symptoms, and Gut Microbiota : What Are the Relations? A Randomized Controlled Trial in Subjects with Irritable Bowel Syndrome. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455083
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455083
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر