Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine

المؤلفون المشاركون

Chadi, Gerson
Farizatto, Karen L. G.
Coelho, Emerson F.
Fior-Chadi, Debora R.
Ferrari, Merari F. R.

المصدر

International Journal of Hypertension

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-07-31

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Considering that nicotine instantly interacts with central and peripheral nervous systems promoting cardiovascular effects after tobacco smoking, we evaluated the modulation of glutamate, tyrosine hydroxylase (TH), neuropeptide Y (NPY), and substance P (SP) in nodose/petrosal and superior cervical ganglia, as well as TH and NPY in nucleus tractus solitarii (NTS) and hypothalamic paraventricular nucleus (PVN) of normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) after 8 weeks of nicotine exposure.

Immunohistochemical and in situ hybridization data demonstrated increased expression of TH in brain and ganglia related to blood pressure control, preferentially in SHR, after nicotine exposure.

The alkaloid also increased NPY immunoreactivity in ganglia, NTS, and PVN of SHR, in spite of decreasing its receptor (NPY1R) binding in NTS of both strains.

Nicotine increased SP and glutamate in ganglia.

In summary, nicotine positively modulated the studied variables in ganglia while its central effects were mainly constrained to SHR.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ferrari, Merari F. R.& Coelho, Emerson F.& Farizatto, Karen L. G.& Chadi, Gerson& Fior-Chadi, Debora R.. 2011. Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-455313

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ferrari, Merari F. R.…[et al.]. Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine. International Journal of Hypertension No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-455313

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ferrari, Merari F. R.& Coelho, Emerson F.& Farizatto, Karen L. G.& Chadi, Gerson& Fior-Chadi, Debora R.. Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-455313

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-455313