Tuberculosis Is Not a Risk Factor for Primary Biliary Cirrhosis : A Review of the Literature

المؤلفون المشاركون

Bogdanos, Dimitrios P.
Liaskos, Christos
Billinis, Charalambos
Smyk, Daniel S.
Rigopoulou, Eirini I.
Pares, Albert
Burroughs, Andrew K.

المصدر

Tuberculosis Research and Treatment

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-10-30

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض

الملخص EN

Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterised serologically by cholestasis and the presence of high-titre antimitochondrial antibodies, and histologically by chronic nonsuppurative cholangitis and granulomata.

As PBC is a granulomatous disease and Mycobacterium tuberculosis is the most frequent cause of granulomata, a causal relation between tuberculosis and PBC has been suggested.

Attempts to find serological evidence of PBC-specific autoantibodies such as AMA have been made and, conversely, granulomatous livers from patients with PBC have been investigated for molecular evidence of Mycobacterium tuberculosis.

This paper discusses in detail the reported data in support or against an association between Mycobacterium tuberculosis infection and PBC.

We discuss the immunological and microbiological data exploring the association of PBC with exposure to Mycobacterium tuberculosis.

We also discuss the findings of large epidemiologic studies investigating the association of PBC with preexistent or concomitant disorders and the relevance of these findings with tuberculosis.

Genome-wide association studies in patients with tuberculosis as well as in patients with PBC provide conclusive hints regarding the assumed association between exposure to this mycobacterium and the induction of PBC.

Analysis of these data suggest that Mycobacterium tuberculosis is an unlikely infectious trigger of PBC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Smyk, Daniel S.& Bogdanos, Dimitrios P.& Pares, Albert& Liaskos, Christos& Billinis, Charalambos& Burroughs, Andrew K.…[et al.]. 2012. Tuberculosis Is Not a Risk Factor for Primary Biliary Cirrhosis : A Review of the Literature. Tuberculosis Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455473

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Smyk, Daniel S.…[et al.]. Tuberculosis Is Not a Risk Factor for Primary Biliary Cirrhosis : A Review of the Literature. Tuberculosis Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-455473

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Smyk, Daniel S.& Bogdanos, Dimitrios P.& Pares, Albert& Liaskos, Christos& Billinis, Charalambos& Burroughs, Andrew K.…[et al.]. Tuberculosis Is Not a Risk Factor for Primary Biliary Cirrhosis : A Review of the Literature. Tuberculosis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-455473

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-455473