A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord
المؤلفون المشاركون
Li, Lan
Jang, Bong Geom
Wu, Guang
Suh, Sang Won
Sung, Gi Ho
Park, Hyoung Jin
Kim, Jin Hee
Cho, Jae Youl
Choi, Bo Young
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The present study aimed to evaluate the therapeutic potential of a mushroom extract from Phellinus igniarius in an animal model of multiple sclerosis.
The medicinal mushroom, Phellinus igniarius, contains biologically active compounds that modulate the human immune system.
Experimental autoimmune encephalomyelitis (EAE) was induced by immunization with myelin oligodendrocyte glycoprotein (MOG 35–55) in C57BL/6 female mice.
A water-ethanol extract of Phellinus igniarius (Piwep) was delivered intraperitoneally every other day for the entire experimental course.
Three weeks after the initial immunization, demyelination and immune cell infiltration in the spinal cord were examined.
Piwep injection profoundly decreased the daily incidence rate and clinical score of EAE.
The Piwep-mediated inhibition of the clinical course of EAE was accompanied by suppression of demyelination and infiltration of encephalitogenic immune cells including CD4+ T cells, CD8+ T cells, macrophages, and B cells in the spinal cord.
Piwep reduced expression of vascular cell adhesion molecule-1 (VCAM-1) in the spinal cord and integrin-α4 in the lymph node of EAE mice.
Piwep also inhibited proliferation of lymphocytes and secretion of interferon-γ in the lymph node of EAE mice.
The results suggest that a mushroom extract, Piwep, may have a high therapeutic potential for ameliorating multiple sclerosis progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Lan& Wu, Guang& Choi, Bo Young& Jang, Bong Geom& Kim, Jin Hee& Sung, Gi Ho…[et al.]. 2014. A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-455480
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Lan…[et al.]. A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-455480
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Lan& Wu, Guang& Choi, Bo Young& Jang, Bong Geom& Kim, Jin Hee& Sung, Gi Ho…[et al.]. A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-455480
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455480
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر