Impact of GLP-1 Receptor Agonists on Major Gastrointestinal Disorders for Type 2 Diabetes Mellitus : A Mixed Treatment Comparison Meta-Analysis
المؤلفون المشاركون
Sun, Feng
Yu, Kai
Yang, Zhirong
Zhang, Yuan
Wu, Shanshan
Shi, Luwen
Ji, Linong
Zhan, Siyan
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Aim.
We aimed to integrate evidence from all randomized controlled trials (RCTs) and assess the impact of different doses of exenatide or liraglutide on major gastrointestinal adverse events (GIAEs) in type 2 diabetes (T2DM).
Methods.
RCTs evaluating different doses of exenatide and liraglutide against placebo or an active comparator with treatment duration ≥4 weeks were searched and reviewed.
A total of 35, 32 and 28 RCTs met the selection criteria evaluated for nausea, vomiting, and diarrhea, respectively.
Pairwise random-effects meta-analyses and mixed treatment comparisons (MTC) of all RCTs were performed.
Results.
All GLP-1 dose groups significantly increased the probability of nausea, vomiting and diarrhea relative to placebo and conventional treatment.
MTC meta-analysis showed that there was 99.2% and 85.0% probability, respectively, that people with exenatide 10 μg twice daily (EX10BID) was more vulnerable to nausea and vomiting than those with other treatments.
There was a 78.90% probability that liraglutide 1.2 mg once daily (LIR1.2) has a higher risk of diarrhea than other groups.
A dose-dependent relationship of exenatide and liraglutide on GIAEs was observed.
Conclusions.
Our MTC meta-analysis suggests that patients should be warned about these GIAEs in early stage of treatment by GLP-1s, especially by EX10BID and LIR1.2, to promote treatment compliance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Feng& Yu, Kai& Yang, Zhirong& Wu, Shanshan& Zhang, Yuan& Shi, Luwen…[et al.]. 2012. Impact of GLP-1 Receptor Agonists on Major Gastrointestinal Disorders for Type 2 Diabetes Mellitus : A Mixed Treatment Comparison Meta-Analysis. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-455706
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Feng…[et al.]. Impact of GLP-1 Receptor Agonists on Major Gastrointestinal Disorders for Type 2 Diabetes Mellitus : A Mixed Treatment Comparison Meta-Analysis. Experimental Diabetes Research No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-455706
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Feng& Yu, Kai& Yang, Zhirong& Wu, Shanshan& Zhang, Yuan& Shi, Luwen…[et al.]. Impact of GLP-1 Receptor Agonists on Major Gastrointestinal Disorders for Type 2 Diabetes Mellitus : A Mixed Treatment Comparison Meta-Analysis. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-455706
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455706
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر