Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study
المؤلفون المشاركون
Dwyer, Michael G.
Seidl, Zdeněk
Zivadinov, Robert
Vaneckova, Manuela
Bergsland, Niels
Dolezal, Ondrej
Krasensky, Jan
Horakova, Dana
Ramasamy, Deepa P.
Havrdova, Eva
Tekwe, Carmen
المصدر
Multiple Sclerosis International
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We investigated the evolution of cortical atrophy in patients with early relapsing-remitting (RR) multiple sclerosis (MS) and its association with lesion volume (LV) accumulation and disability progression.
136 of 181 RRMS patients who participated in the Avonex-Steroids-Azathioprine study were assessed bimonthly for clinical and MRI outcomes over 2 years.
MS patients with disease duration (DD) at baseline of ≤24 months were classified in the early group (DD of 1.2 years, n=37), while patients with DD > 24 months were classified in the late group (DD of 7.1 years, n=99).
Mixed effect model analysis was used to investigate the associations.
Significant changes in whole brain volume (WBV) (P<0.001), cortical volume (CV) (P<0.001), and in T2-LV (P<0.001) were detected.
No significant MRI percent change differences were detected between early and late DD groups over 2 years, except for increased T2-LV accumulation between baseline and year 2 in the early DD group (P<0.01).
No significant associations were found between changes in T2-LV and CV over the followup.
Change in CV was related to the disability progression over the 2 years, after adjusting for DD (P=0.01).
Significant cortical atrophy, independent of T2-LV accumulation, occurs in early RRMS over 2 years, and it is associated with the disability progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zivadinov, Robert& Tekwe, Carmen& Bergsland, Niels& Dolezal, Ondrej& Havrdova, Eva& Krasensky, Jan…[et al.]. 2013. Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study. Multiple Sclerosis International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-455776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zivadinov, Robert…[et al.]. Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study. Multiple Sclerosis International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-455776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zivadinov, Robert& Tekwe, Carmen& Bergsland, Niels& Dolezal, Ondrej& Havrdova, Eva& Krasensky, Jan…[et al.]. Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study. Multiple Sclerosis International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-455776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر