Persistent Comorbidities in Cushing’s Syndrome after Endocrine Cure
المؤلف
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-04
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
It was assumed that resolution of hypercortisolism in Cushing syndrome (CS) was followed by normalization of morbidity; however, in the last decade evidence is accumulating that patients with cured CS still have increased morbidity and mortality after the biochemical control of hypercortisolism.
Patients with CS have an increased cardiovascular and metabolic risk and persistent accumulation of central fat, with an unfavorable adipokine profile, not only during the active phase of the disease but also long after biochemical remission.
Clinical management should be particularly careful in identifying global cardiovascular risk, as a primary goal during the followup of these patients, aimed at improving global vascular morbidity.
Moreover bone mass is reduced not only due to the endogenous hypercortisolism but also due to duration and dose of exogenous glucocorticoid (GC) replacement therapy after surgery.
Thus, therapy in operated patients with inhibition of the hypothalamic-pituitary-adrenal axis should be reduced to the lowest dose and duration possible.
Specific treatments should be considered in patients with decreased bone mass, aimed at reducing the increased fracture incidence.
Finally, cognitive and health related quality of life impairments, described in active disease, are still abnormal after endocrine cure.
Thus, residual morbidity persists in cured CS, suggesting irreversibility of GC-induced phenomena, typical of chronic hypercortisolism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Resmini, Eugenia. 2014. Persistent Comorbidities in Cushing’s Syndrome after Endocrine Cure. Advances in Endocrinology،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-455784
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Resmini, Eugenia. Persistent Comorbidities in Cushing’s Syndrome after Endocrine Cure. Advances in Endocrinology No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-455784
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Resmini, Eugenia. Persistent Comorbidities in Cushing’s Syndrome after Endocrine Cure. Advances in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-455784
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455784
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر