Protective Efficacy of the Calicivirus Valency of the Leucofeligen Vaccine against a Virulent Heterologous Challenge in Kittens
المؤلفون المشاركون
Gueguen, Sylvie
Lesbros, Cynthia
Sanquer, Annaele
Martin, Virginie
Najbar, Wojciech
Eun, Hyone-Myong
Mcgahie, David
المصدر
Veterinary Medicine International
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Feline calicivirus (FCV) is a common feline pathogen with a potential for antigenic diversity.
This study aimed to evaluate and characterize the protective efficacy of the FCV-F9 valency of a tetravalent vaccine, Leucofeligen, against challenge with an unrelated strain.
Ten 9-week-old kittens were vaccinated while 10 remained as unvaccinated controls.
The vaccinated cats received Leucofeligen twice subcutaneously with a 3-week interval.
Four weeks after the second vaccination, all cats were challenged with virulent heterologous FCV and followed up for 21 days, monitoring their general condition, clinical signs, and immunological responses.
During the vaccination phase, rectal temperatures and body weights were indistinguishable between the two groups.
Only vaccinated cats showed FCV-specific seroconversion (both total and neutralizing antibodies).
In the first week after challenge, the vaccinated cats had an 82.6% reduction in median clinical score compared to controls.
Leucofeligen was thus shown to provide a significant clinical protection to kittens challenged with heterologous virulent FCV.
This protection was similar whether the cats had neutralizing antibody or not, indicating a key role for cellular immunity in the overall protection.
This also suggests that previously reported seroneutralisation studies may underestimate the level of cross-protection against field strains obtained with this modified live FCV-F9 vaccine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lesbros, Cynthia& Martin, Virginie& Najbar, Wojciech& Sanquer, Annaele& Mcgahie, David& Eun, Hyone-Myong…[et al.]. 2013. Protective Efficacy of the Calicivirus Valency of the Leucofeligen Vaccine against a Virulent Heterologous Challenge in Kittens. Veterinary Medicine International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-455884
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lesbros, Cynthia…[et al.]. Protective Efficacy of the Calicivirus Valency of the Leucofeligen Vaccine against a Virulent Heterologous Challenge in Kittens. Veterinary Medicine International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-455884
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lesbros, Cynthia& Martin, Virginie& Najbar, Wojciech& Sanquer, Annaele& Mcgahie, David& Eun, Hyone-Myong…[et al.]. Protective Efficacy of the Calicivirus Valency of the Leucofeligen Vaccine against a Virulent Heterologous Challenge in Kittens. Veterinary Medicine International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-455884
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455884
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر