5-Aminolevulinic Acid Fluorescence in High Grade Glioma Surgery : Surgical Outcome, Intraoperative Findings, and Fluorescence Patterns
المؤلفون المشاركون
Ciccarino, Pietro
Rolma, Giuseppe
Rossetto, Marta
Della Puppa, Alessandro
Cecchin, Diego
Lombardi, Giuseppe
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
5-Aminolevulinic acid (5-ALA) fluorescence is a validated technique for resection of high grade gliomas (HGG); the aim of this study was to evaluate the surgical outcome and the intraoperative findings in a consecutive series of patients.
Methods.
Clinical and surgical data from patients affected by HGG who underwent surgery guided by 5-ALA fluorescence at our Department between June 2011 and February 2014 were retrospectively evaluated.
Surgical outcome was evaluated by assessing the resection rate as gross total resection (GTR)>98% and GTR>90%.
We finally stratified data for recurrent surgery, tumor location, tumor size, and tumor grade (IV versus III grade sec.
WHO).
Results.
94 patients were finally enrolled.
Overall GTR>98% and GTR>90% was achieved in 93% and 100% of patients.
Extent of resection (GTR>98%) was dependent on tumor location, tumor grade (P<0.05), and tumor size (P<0.05).
In 43% of patients the boundaries of fluorescent tissue exceeded those of tumoral tissue detected by neuronavigation, more frequently in larger (57%) (P<0.01) and recurrent (60%) tumors.
Conclusions.
5-ALA fluorescence in HGG surgery enables a GTR in 100% of cases even if selection of patients remains a main bias.
Recurrent surgery, and location, size, and tumor grade can predict both the surgical outcome and the intraoperative findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Della Puppa, Alessandro& Ciccarino, Pietro& Lombardi, Giuseppe& Rolma, Giuseppe& Cecchin, Diego& Rossetto, Marta. 2014. 5-Aminolevulinic Acid Fluorescence in High Grade Glioma Surgery : Surgical Outcome, Intraoperative Findings, and Fluorescence Patterns. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-455904
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Della Puppa, Alessandro…[et al.]. 5-Aminolevulinic Acid Fluorescence in High Grade Glioma Surgery : Surgical Outcome, Intraoperative Findings, and Fluorescence Patterns. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-455904
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Della Puppa, Alessandro& Ciccarino, Pietro& Lombardi, Giuseppe& Rolma, Giuseppe& Cecchin, Diego& Rossetto, Marta. 5-Aminolevulinic Acid Fluorescence in High Grade Glioma Surgery : Surgical Outcome, Intraoperative Findings, and Fluorescence Patterns. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-455904
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455904
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر