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Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes : A Study Performed in an Irish Cohort of Pregnant Women
المؤلفون المشاركون
Murray, Margaret
Sedano-Balbás, Sara
Lyons, Mark
Gaffney, Geraldine
Maher, Majella
Cleary, Brendan
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The combination of thrombophilia and pregnancy increases the risk of thrombosis and the potential for adverse outcomes during pregnancy.
The most significant common inherited risk factor for thrombophilia is activated protein C resistance (APCR), a poor anticoagulant response of APC in haemostasis, which is mainly caused by an inherited single-nucleotide polymorphism (SNP), factor V G1691A (FV Leiden) (FVL), referred as inherited APCR.
Changes in the levels of coagulation factors: FV, FVIII, and FIX, and anticoagulant factors: protein S (PS) and protein C (PC) can alter APC function causing acquired APCR.
Prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T are prothrombotic SNPs which in association with APCR can also increase the risk of thrombosis amongst Caucasians.
In this study, a correlation between an acquired APCR phenotype and increased levels of factors V, VIII, and IX was demonstrated.
Thrombophilic mutations amongst our acquired APCR pregnant women cohort are relatively common but do not appear to exert a severe undue adverse effect on pregnancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sedano-Balbás, Sara& Lyons, Mark& Cleary, Brendan& Murray, Margaret& Gaffney, Geraldine& Maher, Majella. 2011. Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes : A Study Performed in an Irish Cohort of Pregnant Women. Journal of Pregnancy،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-455931
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sedano-Balbás, Sara…[et al.]. Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes : A Study Performed in an Irish Cohort of Pregnant Women. Journal of Pregnancy No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-455931
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sedano-Balbás, Sara& Lyons, Mark& Cleary, Brendan& Murray, Margaret& Gaffney, Geraldine& Maher, Majella. Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes : A Study Performed in an Irish Cohort of Pregnant Women. Journal of Pregnancy. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-455931
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-455931
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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