Surgical Treatment and Survival in Patients with Liver Metastases from Neuroendocrine Tumors : A Meta-Analysis of Observational Studies
المؤلفون المشاركون
Uzzau, Alessandro
Londero, Ambrogio P.
Pasqual, Enrico Maria
Bertozzi, Serena
Bacchetti, Stefano
المصدر
International Journal of Hepatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
The role of hepatic resection in patients with liver metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is still poorly defined.
Therefore, we examined the results obtained with surgical resection and other locoregional or systemic therapies by reviewing the recent literature on this topic.
We performed the meta-analysis for comparing surgical resection of hepatic metastases with other treatments.
Materials and Methods.
In this systematic review and meta-analysis of observational studies, the literature search was undertaken between 1990 and 2012 looking for studies evaluating the different survivals between patients treated with surgical resection of hepatic metastases and with other surgical or nonsurgical therapies.
The studies were evaluated for quality, publication bias, and heterogeneity.
Pooled hazard ratio (HR) estimates and 95% confidence intervals (CI.95) were calculated using fixed-effects model.
Results.
We selected six studies in the review, five of which were suitable for meta-analysis.
We found a significant longer survival in patients treated with hepatic resection than embolisation HR 0.34 (CI.95 0.21–0.55) or all other nonsurgical treatments HR 0.45 (CI.95 0.34–0.60).
Only one study compared surgical resection with liver transplantation and meta-analysis was not feasible.
Conclusions.
Our meta-analysis provides evidence supporting the hypothesis that hepatic resection increases overall survival in patients with liver metastases from GEP-NETs.
Further randomized clinical trials are needed to confirm these findings and it would be desirable to identify new markers to properly select patients for surgical treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bacchetti, Stefano& Bertozzi, Serena& Londero, Ambrogio P.& Uzzau, Alessandro& Pasqual, Enrico Maria. 2013. Surgical Treatment and Survival in Patients with Liver Metastases from Neuroendocrine Tumors : A Meta-Analysis of Observational Studies. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-456031
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bacchetti, Stefano…[et al.]. Surgical Treatment and Survival in Patients with Liver Metastases from Neuroendocrine Tumors : A Meta-Analysis of Observational Studies. International Journal of Hepatology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-456031
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bacchetti, Stefano& Bertozzi, Serena& Londero, Ambrogio P.& Uzzau, Alessandro& Pasqual, Enrico Maria. Surgical Treatment and Survival in Patients with Liver Metastases from Neuroendocrine Tumors : A Meta-Analysis of Observational Studies. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-456031
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456031
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر