Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy
المؤلفون المشاركون
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-13
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The concept of a carbimazole embryopathy underlies current Endocrine Society advice to avoid this drug in early pregnancy, favouring propylthiouracil as an alternative for the treatment of maternal hyperthyroidism.
We aimed to establish whether suspected spontaneous reporting of adverse drug reactions in the UK via the Yellow Card Scheme supports a carbimazole embryopathy and the lack of association between propylthiouracil and congenital anomalies.
All birth defects related to maternal treatment with carbimazole or propylthiouracil reported over a 47-year period via the Yellow Card Scheme were analysed.
57 cases with 97 anomalies were reported following in utero exposure to carbimazole.
These anomalies included aplasia cutis, choanal atresia, tracheo-oesophageal fistula, and patent vitellointestinal duct, which have previously been reported in association with carbimazole/methimazole exposure in utero.
Only 6 cases with 11 anomalies were reported for propylthiouracil, all within the last 15 years.
Therefore, these findings may support a carbimazole embryopathy.
There are few birth defects associated with propylthiouracil, but this should be interpreted in the context of higher historical prescription rates for carbimazole.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bowman, Pamela& Vaidya, Bijay. 2011. Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-456035
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bowman, Pamela& Vaidya, Bijay. Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy. Journal of Thyroid Research No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-456035
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bowman, Pamela& Vaidya, Bijay. Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-456035
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456035
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر