Rifaximin versus Nonabsorbable Disaccharides for the Treatment of Hepatic Encephalopathy : A Meta-Analysis
المؤلفون المشاركون
Lu, Jie
Wu, Shu-Mei
Zhou, Ying-Qun
Guo, Chuan-Yong
Xu, Ling
Wu, Dong
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Many studies have found that the antibiotic rifaximin is effective for the treatment of hepatic encephalopathy.
However, there is no uniform view on the efficacy and safety of rifaximin.
Methods.
We performed a meta-analysis through electronic searches to evaluate the efficacy and safety of rifaximin in comparison with nonabsorbable disaccharides.
Results.
A total of 8 randomized controlled trials including 407 patients were included.
The efficacy of rifaximin was equivalent to nonabsorbable disaccharides according to the statistical data (risk ratio (RR): 1.06, 95% CI: 0.94–1.19; P=0.34).
Analysis showed that patients treated with rifaximin had better results in serum ammonia levels (weighted mean difference (WMD): −10.63, 95% CI: −30.63–9.38; P=0.30), mental status (WMD: −0.32, 95% CI: −0.67–0.03; P=0.07), asterixis (WMD: −0.12, 95% CI: −0.31–0.08; P=0.23), electroencephalogram response (WMD: −0.21, 95% CI: −0.34–−0.09; P=0.0007), and grades of portosystemic encephalopathy (WMD: −2.30, 95% CI: −2.78–−1.82; P<0.00001), but only the last ones had statistical significance.
The safety of rifaximin was better than nonabsorbable disaccharides (RR: 0.19, 95% CI: 0.10–0.34; P<0.00001).
Conclusion.
Rifaximin is at least as effective as nonabsorbable disaccharides, maybe better for the treatment of hepatic encephalopathy.
And the safety of rifaximin is better.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Dong& Wu, Shu-Mei& Lu, Jie& Zhou, Ying-Qun& Xu, Ling& Guo, Chuan-Yong. 2013. Rifaximin versus Nonabsorbable Disaccharides for the Treatment of Hepatic Encephalopathy : A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456203
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Dong…[et al.]. Rifaximin versus Nonabsorbable Disaccharides for the Treatment of Hepatic Encephalopathy : A Meta-Analysis. Gastroenterology Research and Practice No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-456203
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Dong& Wu, Shu-Mei& Lu, Jie& Zhou, Ying-Qun& Xu, Ling& Guo, Chuan-Yong. Rifaximin versus Nonabsorbable Disaccharides for the Treatment of Hepatic Encephalopathy : A Meta-Analysis. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456203
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456203
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر