Graptopetalum paraguayense Ameliorates Airway Inflammation and Allergy in Ovalbumin- (OVA-) Sensitized BALBC Mice by Inhibiting Th2 Signal
المؤلفون المشاركون
Wu, She-Ching
Cheng, Yu-Hsiang
Lee, Bao-Hong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-17
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Role of inflammation-induced oxidative stress in the pathogenesis and progression of chronic inflammatory airways diseases has received increasing attention in recent years.
Nuclear factor erythroid 2-related factor 2 is the primary transcription factor that regulates the expression of antioxidant and detoxifying enzymes.
Graptopetalum paraguayense E.
Walther, a vegetable consumed in Taiwan, has been used in folk medicine for protection against liver injury through elevating antioxidation.
Recently, we found that gallic acid is an active compound of Graptopetalum paraguayense E.
Walther, which has been reported to inhibit T-helper 2 cytokines.
Currently, we assumed that Graptopetalum paraguayense E.
Walther may potentially protect against ovalbumin-induced allergy and airway inflammation.
Results demonstrated that Graptopetalum paraguayense E.
Walther ethanolic extracts (GPE) clearly inhibited airway inflammation, mucus cell hyperplasia, and eosinophilia in OVA-challenged mice.
Additionally, GPE also prevented T-cell infiltration and Th2 cytokines, including interleukin- (IL-)4, IL-5, and IL-13 generations in bronchial alveolar lavage fluid.
The adhesion molecules ICAM-1 and VCAM-1 were substantially reduced by GPE treatment mediated by Nrf2 activation.
Moreover, GPE attenuated GATA3 expression and inhibited Th2 signals of the T cells.
These findings suggested that GPE ameliorated the development of airway inflammation through immune regulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Bao-Hong& Cheng, Yu-Hsiang& Wu, She-Ching. 2013. Graptopetalum paraguayense Ameliorates Airway Inflammation and Allergy in Ovalbumin- (OVA-) Sensitized BALBC Mice by Inhibiting Th2 Signal. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-456221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Bao-Hong…[et al.]. Graptopetalum paraguayense Ameliorates Airway Inflammation and Allergy in Ovalbumin- (OVA-) Sensitized BALBC Mice by Inhibiting Th2 Signal. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-456221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Bao-Hong& Cheng, Yu-Hsiang& Wu, She-Ching. Graptopetalum paraguayense Ameliorates Airway Inflammation and Allergy in Ovalbumin- (OVA-) Sensitized BALBC Mice by Inhibiting Th2 Signal. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-456221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر