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Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington’s-Like Symptoms
المؤلفون المشاركون
Cho, Ik-Hyun
Jang, Minhee
Kim, Cheon Suk
Lee, Min Jung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-27
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Korean red ginseng (KRG) possesses neuroprotective activity.
However, the potential neuroprotective value of KRG for the striatal toxicity is largely unknown.
We investigated whether KRG extract (KRGE) could have a neuroprotective effect in a 3-nitropropionic acid- (3-NP) induced (i.p.) Huntington’s disease (HD) model.
KRGE (50, 100, and 250 mg/kg/day, p.o.) was administrated 10 days before 3-NP injection (pre-administration), from the same time with 3-NP injection (co-administration), or from the peak point of neurological impairment by 3-NP injection (post-administration).
Pre-administration of KRGE produced the greatest neuroprotective effect in this model.
Pre-administration of KRGE significantly decreased 3-NP-induced neurological impairment, lethality, lesion area, and neuronal loss in the 3-NP-injected striatum.
KRGE attenuated microglial activation and phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) signal pathway.
KRGE also reduced the level of mRNA expression of tumor necrosis factor-alpha, interleukin- (IL-) 1β, IL-6, inducible nitric oxide synthase, and OX-42.
Interestingly, the intrathecal administration of SB203580 (a p38 inhibitor) or PD98059 (an inhibitor of MAPK Kinase, MEK) increased the survival rate in the 3-NP-induced HD model.
Pre-administration of KRGE may effectively inhibit 3-NP-induced striatal toxicity via the inhibition of the phosphorylation of MAPKs and NF-κB pathways, indicating its therapeutic potential for suppressing Huntington’s-like symptoms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jang, Minhee& Lee, Min Jung& Kim, Cheon Suk& Cho, Ik-Hyun. 2013. Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington’s-Like Symptoms. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-456228
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jang, Minhee…[et al.]. Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington’s-Like Symptoms. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-456228
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jang, Minhee& Lee, Min Jung& Kim, Cheon Suk& Cho, Ik-Hyun. Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington’s-Like Symptoms. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-456228
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456228
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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