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Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies
المؤلفون المشاركون
Anand, Lovkesh
Rastogi, Archana
Bihari, Chhagan
Saxena, Priyanka
Agarwal, Savita
Sarin, Shiv Kumar
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Liver disease patients have complex hemostatic defects leading to a delicate, unstable balance between bleeding and thrombosis.
Conventional tests such as PT and APTT are unable to depict these defects completely.
Aims.
This study aimed at analyzing the abnormal effects of liver disease on sonoclot signature by using sonoclot analyzer (which depicts the entire hemostatic pathway) and assessing the correlations between sonoclot variables and conventional coagulation tests.
Material and Methods.
Clinical and laboratory data from fifty inpatients of four subgroups of liver disease, including decompensated cirrhosis, chronic hepatitis, cirrhosis with HCC and acute-on-chronic liver failure were analyzed.
All patients and controls were subjected to sonoclot analysis and correlated with routine coagulation parameters including platelet count, PT, APTT, fibrinogen, and D-dimer.
Results.
The sonoclot signatures demonstrated statistically significant abnormalities in patients with liver disease as compared to healthy controls.
PT and APTT correlated positively with SONACT (P<0.008 and <0.0015, resp.) while platelet count and fibrinogen levels depicted significant positive and negative correlations with clot rate and SONACT respectively.
Conclusion.
Sonoclot analysis may prove to be an efficient tool to assess coagulopathies in liver disease patients.
Clot rate could emerge as a potential predictor of hypercoagulability in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saxena, Priyanka& Bihari, Chhagan& Rastogi, Archana& Agarwal, Savita& Anand, Lovkesh& Sarin, Shiv Kumar. 2013. Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies. Advances in Hematology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456237
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saxena, Priyanka…[et al.]. Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies. Advances in Hematology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-456237
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saxena, Priyanka& Bihari, Chhagan& Rastogi, Archana& Agarwal, Savita& Anand, Lovkesh& Sarin, Shiv Kumar. Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies. Advances in Hematology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456237
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456237
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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