Hemeoxygenase-1 Mediates an Adaptive Response to Spermidine-Induced Cell Death in Human Endothelial Cells

المؤلفون المشاركون

Park, Hye Rim
Kim, Gun-Dong
Lee, Seung Eun
Yang, Hana
Park, Yong Seek

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-08-04

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

Spermidine (SPD) is a ubiquitous polycation that is commonly distributed in living organisms.

Intracellular levels of SPD are tightly regulated, and SPD controls cell proliferation and death.

However, SPD undergoes oxidation in the presence of serum, producing aldehydes, hydrogen peroxide, and ammonia, which exert cytotoxic effect on cells.

Hemeoxygenase-1 (HO-1) is thought to have a protective effect against oxidative stress.

Upregulation of HO-1 in endothelial cells is considered to be beneficial in the cardiovascular disease.

In the present study, we demonstrate that the ubiquitous polyamine, SPD, induces HO-1 in human umbilical vein endothelial cells (HUVECs).

SPD-induced HO-1 expression was examined by Western blot and reverse transcription-polymerase chain reaction (RT-PCR).

Involvement of reactive oxygen species, serum amine oxidase, PI3K/Akt signaling pathway, and transcription factor Nrf2 in the induction of HO-1 by SPD was also investigated.

Furthermore, small interfering RNA knockdown of Nrf2 or HO-1 and treatment with the specific HO-1 inhibitor ZnPP exhibited a noteworthy increase of death of SPD-stimulated HUVECs.

In conclusion, these results suggest that SPD induces PI3K/Akt-Nrf2-mediated HO-1 expression in human endothelial cells, which may have a role in cytoprotection of the cells against oxidative stress-induced death.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yang, Hana& Lee, Seung Eun& Kim, Gun-Dong& Park, Hye Rim& Park, Yong Seek. 2013. Hemeoxygenase-1 Mediates an Adaptive Response to Spermidine-Induced Cell Death in Human Endothelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456385

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yang, Hana…[et al.]. Hemeoxygenase-1 Mediates an Adaptive Response to Spermidine-Induced Cell Death in Human Endothelial Cells. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-456385

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yang, Hana& Lee, Seung Eun& Kim, Gun-Dong& Park, Hye Rim& Park, Yong Seek. Hemeoxygenase-1 Mediates an Adaptive Response to Spermidine-Induced Cell Death in Human Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456385

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-456385