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Mycobacterium tuberculosis Complex Genotype Diversity and Drug Resistance Profiles in a Pediatric Population in Mexico
المؤلفون المشاركون
Kumate Rodríguez, Jesús
Macías Parra, Mercedes
Balandrano, Susana
Castañón-Arreola, Mauricio
Arredondo García, José Luís
Gutiérrez Castrellón, Pedro
Rastogi, Nalin
López-Vidal, Yolanda
المصدر
Tuberculosis Research and Treatment
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this study was to determine the frequency of drug resistance and the clonality of genotype patterns in M.
tuberculosis clinical isolates from pediatric patients in Mexico (n=90 patients from 19 states; time period—January 2002 to December 2003).
Pulmonary disease was the most frequent clinical manifestation (71%).
Children with systemic tuberculosis (TB) were significantly younger compared to patients with localized TB infections (mean 7.7±6.2 years versus 15±3.4 years P=0.001).
Resistance to any anti-TB drug was detected in 24/90 (26.7%) of the isolates; 21/90 (23.3%) and 10/90 (11.1%) were resistant to Isoniazid and Rifampicin, respectively, and 10/90 (11.1%) strains were multidrug-resistant (MDR).
Spoligotyping produced a total of 55 different patterns; 12/55 corresponded to clustered isolates (n=47, clustering rate of 52.2%), and 43/55 to unclustered isolates (19 patterns were designated as orphan by the SITVIT2 database).
Database comparison led to designation of 36 shared types (SITs); 32 SITs (n=65 isolates) matched a preexisting shared type in SITVIT2, whereas 4 SITs (n=6 isolates) were newly created.
Lineage classification based on principal genetic groups (PGG) revealed that 10% of the strains belonged to PGG1 (Bovis and Manu lineages).
Among PGG2/3 group, the most predominant clade was the Latin-American and Mediterranean (LAM) in 27.8% of isolates, followed by Haarlem and T lineages.
The number of single drug-resistant (DR) and multidrug-resistant (MDR-TB) isolates in this study was similar to previously reported in studies from adult population with risk factors.
No association between the spoligotype, age, region, or resistance pattern was observed.
However, contrary to a study on M.
tuberculosis spoligotyping in Acapulco city that characterized a single cluster of SIT19 corresponding to the EAI2-Manila lineage in 70 (26%) of patients, not a single SIT19 isolate was found in our pediatric patient population.
Neither did we find any shared type belonging to the EAI family which represents ancestral PGG1 strains within the M.
tuberculosis complex.
We conclude that the population structure of pediatric TB in our setting is different from the one prevailing in adult TB patient population of Guerrero.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Macías Parra, Mercedes& Kumate Rodríguez, Jesús& Arredondo García, José Luís& López-Vidal, Yolanda& Castañón-Arreola, Mauricio& Balandrano, Susana…[et al.]. 2011. Mycobacterium tuberculosis Complex Genotype Diversity and Drug Resistance Profiles in a Pediatric Population in Mexico. Tuberculosis Research and Treatment،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456411
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Macías Parra, Mercedes…[et al.]. Mycobacterium tuberculosis Complex Genotype Diversity and Drug Resistance Profiles in a Pediatric Population in Mexico. Tuberculosis Research and Treatment No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-456411
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Macías Parra, Mercedes& Kumate Rodríguez, Jesús& Arredondo García, José Luís& López-Vidal, Yolanda& Castañón-Arreola, Mauricio& Balandrano, Susana…[et al.]. Mycobacterium tuberculosis Complex Genotype Diversity and Drug Resistance Profiles in a Pediatric Population in Mexico. Tuberculosis Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456411
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456411
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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