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Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension
المؤلف
المصدر
International Journal of Hypertension
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Basic research using animal models points to a causal role of the central nervous system in essential hypertension; however, since clinical research is technically difficult to perform, this connection has not been confirmed in humans.
Recently, renal nerve ablation in humans proved to continuously decrease blood pressure in resistant hypertension.
Furthermore, when electrical stimulation was continuously applied to the carotid baroreceptor nerve of human adults, their blood pressure lowered.
These findings promoted the concept that the central nervous system may actually be involved in the pathogenesis of essential hypertension, which is closely associated with excess sodium intake.
We have demonstrated that endogenous digitalis plays a key role in hypertension associated with excess sodium intake via sympathetic activation in rats.
Increased sodium concentration inside the brain activates epithelial sodium channels and the renin-angiotensin-aldosterone system in the brain.
Aldosterone releases ouabain from neurons in the paraventricular nucleus in the hypothalamus.
Angiotensin II and aldosterone of peripheral origin reach the brain to augment sympathetic outflow.
Collectively essential hypertension associated with excess sodium intake and obesity, renovascular hypertension, and primary aldosteronism and pseudoaldosteronism all seem to have a common cause originating from the central nervous system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takahashi, Hakuo. 2012. Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-456738
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takahashi, Hakuo. Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension. International Journal of Hypertension No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-456738
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takahashi, Hakuo. Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-456738
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456738
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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