Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate : An Antimuscarinic Agent
المؤلفون المشاركون
Jadhav, Sanjay A.
Landge, Shashikant B.
Lakshmi Narayana, Ch.
Niphade, Navanath C.
Mathad, Vijayavitthal T.
Gaikwad, Vishwas B.
Dahale, Sunil B.
المصدر
Chromatography Research International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
A new, simple, and rapid stereoselective normal phase-liquid chromatographic (NP-LC) method was developed to separate and quantify the solifenacin succinate and its three stereoisomers.
The stereoisomeric separation was achieved on Chiralpak IC (250×4.6 mm ID) column.
The mobile phase was consisting of n-hexane, ethanol, isopropyl alcohol, and diethylamine in the ratio (60 : 15 : 25 : 0.1, v/v/v/v), and the flow rate was maintained at 1.0 mL min−1.
UV detection was carried out at 220 nm.
In addition, chiroptical detection was carried out using laser polarimeter to understand the elution orders.
Resolution between all the stereoisomers was not less than 3.
Effect of column temperature on resolution between the stereoisomers was studied.
The method was validated as per ICH guideline and found to be robust.
The proposed NP-LC method was successfully applied to the analysis of commercial formulation.
The method could be of use not only for routine evaluation of the quality of solifenacin succinate in bulk drug manufacturing unit but also for detection of impurities in pharmaceutical formulations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Landge, Shashikant B.& Jadhav, Sanjay A.& Dahale, Sunil B.& Niphade, Navanath C.& Lakshmi Narayana, Ch.& Gaikwad, Vishwas B.…[et al.]. 2010. Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate : An Antimuscarinic Agent. Chromatography Research International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-456798
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Landge, Shashikant B.…[et al.]. Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate : An Antimuscarinic Agent. Chromatography Research International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-456798
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Landge, Shashikant B.& Jadhav, Sanjay A.& Dahale, Sunil B.& Niphade, Navanath C.& Lakshmi Narayana, Ch.& Gaikwad, Vishwas B.…[et al.]. Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate : An Antimuscarinic Agent. Chromatography Research International. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-456798
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456798
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر